acarbose

Acarbose (BAY g 5421) is a hypoglycemic agent that is an inhibitor of orally active alpha-glucosidase (IC50=11 nM). Acarbose enhances the hypoglycemic effect of sulfonylureas or insulin.

Acarbose sulfate is an anti-diabetic drug and is an inhibitor of alpha-glucosidase.

Acarbose (Standard) is the standard product of Acarbose, suitable for research such as quantitative analysis, quality control, and biochemical experiments. Acarbose is an orally available inhibitor of α-glucosidase, with hypoglycemic effects.

Sulfaethoxypyridazine is a sulfonamide antibacterial agent that enhances the efficacy of drugs such as Acarbose when used in combination therapy and can induce cataracts in rats and dogs.

α-Glucosidase-IN-82 (compound 8l) is a potent inhibitor of α-glucosidase, with an IC50 value of 13.66 μM. Its inhibitory activity is 52 times greater than that of Acarbose.

α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-glucosidase inhibitor with an IC50 of 2.11 μM, demonstrating greater inhibitory potency than the existing α-glucosidase inhibitors Acarbose (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). It exhibits no cytotoxicity on normal human liver cells (LO2) and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research in type 2 diabetes.

α-Glucosidase-IN-92 (compound 14b) is a non-competitive inhibitor targeting α-glucosidase with an IC50 of 64.0 μM, displaying greater inhibitory potency than Acarbose (IC50=750 μM). It has excellent oral bioavailability and can cross the blood-brain barrier. This compound slows carbohydrate hydrolysis and reduces postprandial blood glucose levels, making it useful for antidiabetic studies in type 2 diabetes.

α-Amylase/α-Glucosidase-IN-22 is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.71 nM and 10.36 nM, respectively (showing potencies 23.8 times and 5 times that of acarbose). It is applicable in the study of metabolic diseases, such as diabetes.

α-Glucosidase-IN-105 is a selective and potent inhibitor of α-glucosidase with an IC50 of 31.36 μM. It also inhibits α-amylase (IC50: 104.2 μM). The inhibitory effects of α-Glucosidase-IN-105 are comparable to those of the standard drug Acarbose. This compound is useful in research related to type 2 diabetes.

Valienamine, an alpha-glucosidase inhibitor, is the crucial functional component of several natural glycosidase inhibitors, such as the crop protectant validamycin A and the antidiabetic agent acarbose [1].

Sulfaethoxypyridazine (Standard) is the standard substance of Sulfaethoxypyridazine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Sulfaethoxypyridazine is a sulfonamide antibacterial agent that enhances the efficacy of drugs such as Acarbose when used in combination therapy and can induce cataracts in rats and dogs.