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By Target- Apoptosis
- Autophagy(1)
- Bcl-2 Family(1)
- Mitophagy(1)
- Others(1)
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Results for "
abt-737
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Isotope Products1
CitedABT-737-d8
TMID-08201217686-68-4
ABT 737-d8 is the deuterated form of ABT-737, a BH3 mimetic and potent inhibitor of Bcl-2, Bcl-xL, and Bcl-w, with EC50 values of 30.3 nM, 78.7 nM, and 197.8 nM respectively. ABT-737 disrupts the BCL-2/BAX complex and activates the intrinsic apoptotic pathway in a BAK-dependent and BIM-independent manner. Additionally, ABT-737 induces autophagy and shows potential for research in acute myeloid leukemia (AML).
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