Tromethamine

Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.

Trometamol hydrochloride (TRIS hydrochloride) (Tromethamine hydrochloride) is a biologically inert amino alcohol with low toxicity. Trometamol hydrochloride buffers carbon dioxide and acids in vitro and in vivo. Trometamol hydrochloride is an effective amine compound for pH control in the physiological range.

Prinomide tromethamine is an antirheumatic compound.

An antibiotic produced by Streptomyces fradiae.

Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities.

Carboprost tromethamine, a synthetic 15-methyl analogue of prostaglandin F2α, effectively promotes uterine contractions and significantly reduces bleeding during and post-delivery.

Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis.

Clesacostat (PF-05221304) is a potent and selective ACC inhibitor, with hACC1 IC50 of 13 nM and hACC2 IC50 of 9 nM. In animal models, PF-05221304 specifically inhibits hepatic DNL and demonstrates a significant safety margin for thrombocytopenia in non-human primate models.

Pemetrexed tromethamine is a chemotherapy drug used for pleural mesothelioma and non-small cell lung cancer.

Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

Palifosfamide (tromethamine), a synthetically derived alkylating agent, exhibits potential antineoplastic properties. Acting as the stabilized active metabolite of ifosfamide, it irreversibly alkylates and crosslinks DNA at GC base pairs, inhibiting DNA replication and inducing cell death. Palifosfamide (tromethamine) boasts reduced toxicity in comparison to ifosfamide.

Loxoprofenol-SRS tromethamine (HR1405-01), the active metabolite of Loxoprofen, is a non-steroidal anti-inflammatory drug (NSAID) intended for intravenous use, known for its superior anti-inflammatory and analgesic properties, making it a safe choice within its category.

Succinic acid tromethamine, a powerful and orally active anxiolytic agent, serves as an intermediate in the tricarboxylic acid (TCA) cycle. This compound is also a precursor for various industrially significant chemicals within the food, chemical, and pharmaceutical sectors [1] [2] [3].

Sudexanox, a flavonoid derivative, has demonstrated potent activity in preclinical studies for the treatment of allergies, allergic asthma, and asthmatic bronchitis, particularly in an IgE-induced passive cutaneous anaphylaxis model in rats.

Cilofexor, also known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilofexor was well tolerated and led to significant improvements in liver biochemistries and markers of cholestasis in patients with PSC.

ATP ditromethamine (Adenosine 5'-triphosphate ditromethamine) is a vital in vivo energy storage and metabolic constituent that fuels metabolic pumps and acts as a cellular coenzyme. It also plays a crucial role as an endogenous signaling molecule in immunity and inflammation [1] [2].

Guanosine 5'-diphosphate ditromethamine (GDP ditromethamine) is a nucleoside diphosphate that activates ATP-sensitive K+ channels. It acts as a potential iron mobilizer, inhibiting the interaction between hepcidin and ferroportin, and modulating the IL-6/STAT-3 pathway. This compound finds application in inflammation research, such as studying anemia of inflammation (AI).

4-Nitrophenyl phosphate ditromethamine is an enzyme substrate frequently employed in biochemical assays to evaluate the activity of various phosphatases, including alkaline phosphatase. Its unique chemical properties allow phosphatases to hydrolyze it, resulting in a yellow product detectable via spectrophotometry.

PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 μg dose reduces intraocular pressure by 68% after the fourth day of treatment.

Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.