T8118

Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic extracted from Streptomyces kanamyceticus, which inhibits a range of Gram-positive and Gram-negative bacteria.

Semastatin-5B, an anti-angiogenic peptide composed of 17 amino acids, can be derived from proteins featuring type I thrombospondin motifs [1].

sEH/FLAP-IN-1 (Compound 46A) serves as a dual inhibitor targeting both sEH and FLAP, effectively suppressing 5-LOX product formation with an EC50 of 11 nM in SACM-stimulated PBMCs, inhibiting sEH activity (EC50: 18 nM), and reducing thromboxane production. This compound is utilized in the study of inflammatory diseases [1].

Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it is stimulated by fatty acids and promotes pancreatic secretion of water and bicarbonate. Secretin has diverse effects on organ systems and is utilized in research on the digestive system, central nervous system, and energy metabolism [1][2].

Sec61-IN-5 (Compound 16c), a Sec61 inhibitor, exhibits cytotoxicity in A549 cells with an IC50 of 0.27 nM and impedes Sec61-dependent secretory function with an IC50 of 0.08 nM [1].

SDH-IN-10 is a potent succinate dehydrogenase inhibitor (SDHI) that exhibits antifungal activity [1].

Scospondistatin, an anti-angiogenic peptide, inhibits both proliferation and migration of human umbilical vein endothelial cells in vitro [1].

Schizolaenone C, a natural compound isolated from Schizolaena hystrix, demonstrates anti-proliferative and anti-oxidative properties [1] [2].