T7439

3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.

VD2173, a macrocyclic peptide inhibitor with a side chain cyclization, effectively inhibits HGF-activating serine proteases including matriptase and hepsin, and is utilized in lung cancer research [1].

OARV-771, a VHL-based BET degrader (PROTAC) featuring enhanced cell permeability, demonstrates DC50 values of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3, respectively [1].

Antimicrobial Photosensitizer-1 demonstrates significant potential as an effective agent for treating infections caused by pathogenic microorganisms, with notable antimicrobial efficacy observed in S. aureus-infected mouse wound models [1].

Antitumor agent-36 exhibits strong anti-proliferative and anti-metastasis capabilities, causing significant DNA damage that results in elevated levels of γ-H2AX and p53. It promotes tumor cell apoptosis via the mitochondrial apoptotic pathway involving Bcl-2/Bax/caspase3 and enhances immune response by inhibiting PD-L1 expression, thereby increasing CD3+ and CD8+ T cell infiltration in tumor tissues [1].

Flupyradifurone (flupyradifurone) is a systemic insecticide and nicotinic acetylcholine receptor (nAChR) agonist that acts by interfering with the nervous system of insects.

Dicloromezotiaz, a potent insecticide, targets nicotinic acetylcholine receptors (nAChRs) to control a broad spectrum of lepidoptera [1].

nAChR modulator-1, an insecticide, is an orthosteric modulator of insect nAChRs [1].

nAChR modulator-2, an insecticide, functions as an orthosteric modulator of insect nAChR [1].

DATPT is a small molecule 12WLVSKF17 peptide mimetic molecule.DATPT inhibits SNX9-p47phox interactions and inhibits the production of reactive oxygen species and inflammatory cytokines.DATPT has anti-inflammatory and antimicrobial activity and acts by decreasing ATP production.DATPT is a potential compound for the treatment of sepsis.

Heterobivalent ligand-1 (compound 26) targets the Adenosine A2A-dopamine D2 receptor heteromer with binding affinities of K DB1 A2A R=2.1 nM and K DB1 D2 R=0.13 nM [1].