T6388

Amprenavir (KVX-478) is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.

DHODH-IN-22 is a potent and selective orally active inhibitor of dihydroorotic dehydrogenase (DHODH) with an IC50 of 0.3 nM, suitable for use in acute myeloid leukaemia (AML) studies.

HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.

BRAF V600E/CRAF-IN-2 is a potent inhibitor of BRAFV600E/CRAF with IC50 values of 0.888 and 0.229 μM, respectively.BRAF V600E/CRAF-IN-2 induces cell cycle arrest at G0/G1 phase and apoptosis in HCT-116 colon cancer cells.BRAF V600E/CRAF-IN-2 has shown research potential for cancer disease. CRAF-IN-2 has shown potential for research into cancer disease.

RAD51-IN-6 is a potent inhibitor of RAD51 (a eukaryotic gene) and has demonstrated potential for the study of mitochondrial deficiency disorders.

IZTZ-1 is a c-MYC G4 ligand, an imidazole-benzothiazole conjugate. c-MYC G4 is stabilized and c-MYC expression is down-regulated by IZTZ-1. c-MYC G4 is a cell cycle blocker and induces apoptosis, and inhibits the proliferation of B16 cells. Melanoma.

c-Met-IN-13 is a potent inhibitor of c-Met (IC50: 2.43 nM) that exhibits significant cytotoxicity and anti-proliferative effects against cancer cells in a concentration-dependent and time-dependent manner, demonstrating therapeutic potential against cancer.

PLK1-IN-4 (compound 31) is a selective PLK1 inhibitor (IC50 < 0.51 nM) exhibiting antiproliferative activity against multiple cancer cell lines including A549, HT-29, and HCT-116. It induces cell cycle arrest and apoptosis, making it suitable for hepatocellular carcinoma research.

SOS1-IN-14 is a selective, potent, orally active SOS1 inhibitor (IC50: 3.9 nM). sOS1-IN-14 is absorbed in the intestine using a P-glycoprotein-mediated efflux mechanism. sOS1-IN-14 can be used in the study of KRAS mutated cancers and is more effective in tumour suppression than BI-3406.

Axl-IN-12 is a potent inhibitor of AXL. Axl-IN-12 can be used to study proliferative, allergic, autoimmune, inflammatory, cancer, transplant rejection, viral infectious diseases or other mammalian diseases.

eeAChE-IN-1 is a strong inhibitor of eeAChE (IC50: 23 nM).