T6269

Bemcentinib (R428) belongs to small molecule inhibitors and is a highly selective oral Axl inhibitor (IC50 = 14 nM) with oral bioavailability and potent cell permeability. This compound effectively inhibits cancer cell migration and invasion, blocks tumor dissemination, and prolongs survival in various tumor models.

HIV-1 inhibitor-46 (compound 13d) is a potent non-nucleoside reverse transcriptase inhibitor of HIV-1 with an EC50 of 1.425 μM. This compound is suitable for use in AIDS research.

Syk Inhibitor II dihydrochloride dihydrate is a highly selective, potent, ATP-competitive Syk inhibitor (IC50: 41 nM) that exhibits anti-allergic effects.

ML-SI1, a racemic mixture of diastereoisomers, is a TRPML inhibitor with an IC50 of 15 μM acting on TRPML1.

Tubulin polymerization-IN-29 is a potent inhibitor of microtubule protein polymerization and shows potent anti-proliferative effects.Tubulin polymerization-IN-29 induces cell cycle arrest in HeLa cells at G2/M phase.

(S)-GFB-12811 (compound 596) is a selective inhibitor of CDK5 (IC50<10 nM) and can be used in studies of cell cycle progression, neuronal development, and tumorigenesis.

GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.

PI3K-IN-30 (compound 6d) is a potent PI3K inhibitor with IC50 values of 5.1 nM for PI3Kα, 136 nM for PI3Kβ, 30.7 nM for PI3Kγ, and 8.9 nM for PI3Kδ.

BuChE-IN-3 (Compound C4) is a potent inhibitor of BuChE (IC50: 8.3 nM), as well as a mild antioxidant, non-toxic, lipophilic, and neuroprotective agent.

mIDH1-IN-1 (compound 43) is a potent and selective inhibitor of mIDH1 (isocitrate dehydrogenase 1 mutant) with an IC50 of 961.5 nM, and it effectively inhibits the production of 2-HG (2-hydroxyglutarate) in HT1080 cells. It also exhibits significant anti-proliferative effects on IDH1 mutant U-87 cells (IC50: 41.8 nM). mIDH1-IN-1 is an anti-tumor agent used to study IDH1 mutant solid tumors.

Glyoxalase I inhibitor 2 (compound 26) is a potent inhibitor of glyoxalase I (GLO1) with an IC50 of 0.5 μM, and has potential applications in depression and anxiety studies.