T6106

Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.

Febuxostat (TEI 6720) sodium has the potential in gout and hyperuricemia research which is a potent, selective and non-purine inhibitor of xanthine oxidase (XO) with a Ki value of 0.6 nM [1] [2] [3].

JH295 hydrate is a potent, irreversible, and selective NIMA-related kinase 2 (Nek2) inhibitor that inhibits cellular Nek2 by Cys22 alkylation (IC50 = 770 nM). JH295 hydrate is not active against the mitotic kinases Cdk1, Aurora B, or Plk1, and does not interfere with bipolar spindle assembly or the spindle assembly checkpoint [1].

ERGi-USU-6 (mesylate) is a new selective ERG-positive prostate cancer inhibitor, with an IC50 of 0.089 μM, and is a salt derivative of ERGi-USU-6.

SEN177 shows the potential in the research of Huntington's disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates [1].

nAChR antagonist 1 (compound B15) is a highly effective antagonist of α7 nAChR, with an IC50 value of 3.3 μM, making it an ideal candidate for investigating the pathogenesis of schizophrenia, Alzheimer's disease, and inflammatory disorders [1].

Lisuride is an orally active agonist of dopamine D2 receptors, classified as an ergot derivative. It is utilized for research purposes relating to Parkinson's disease, migraine, and elevated prolactin levels [1] [2].

MurB-IN-1 (compound 44) is a potent inhibitor of MurB, an essential enzyme involved in the synthesis of the bacterial cell wall. With a binding affinity of Kd 3.57 μM, MurB-IN-1 effectively hinders MurB activity, presenting a promising therapeutic option against P. aeruginosa, a highly virulent and opportunistic pathogen associated with severe infections and mortality [1].

Tubulin polymerization-IN-15 (compound 4) is a potent tubulin polymerization inhibitor with significant potential in cancer research [1].