T6089

Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.

Xanthine oxidoreductase-IN-1 is a xanthine oxidoreductase (XOR) inhibitor with an IC 50 value of 7.0 nM.

AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE, and MAO-B that crosses the blood-brain barrier, exhibiting inhibitory effects on hAChE, hBChE, and hMAO-B with IC50s of 7.31, 0.56, and 26.1 μM, respectively. [AChE/BChE/MAO-B-IN-1] had a neuroprotective effect and was not significantly cytotoxic.

DDO-02001 can be used in anti-arrhythmia research. DDO-02001 is a moderately potent inhibitor of Kv1.5 potassium channel with an IC50 value of 17.7 μM [1].

Ep vinyl quinidine (3-Epiquinine) is an epi-vinyl stereoisomer of Quinidine, which is used in malaria research and acts as an antiarrhythmic agent. Quinidine is a potent, orally active, selective inhibitor of cytochrome P450db and a blocker of K+ channels with an IC50 of 19.9 μM [1] [2] [3].

TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist with demonstrated anti-cancer activity [1].

JAK-2-/3-IN-3 (compound ST4j) is a potent inhibitor of JAK2/3, with IC50 values of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. It inhibits JAK2 autophosphorylation, induces apoptosis in a time- and dose-dependent manner, and can be used in lymph-derived diseases and leukemia research [1].

HER2-IN-11 is a psoralen derivative that induces apoptosis, exhibits light-activated cytotoxicity, and demonstrates anti-breast cancer activity [1].

Aldose reductase-IN-5 is an inhibitor of aldose reductase (ALR2) that enhances the combination of inhibitory excitability and antioxidant capacity, thereby delaying the diabetes complications progress.

IRAK4-IN-11 (compound 6) is a potent IRAK4 inhibitor with an IC50 of 0.008 μM, demonstrating cell pIRAK4 potencies with an IC50 of 0.19 μM [1].