T2666

Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.

ASM-024, a potent nicotinic receptor agonist, is a small molecule synthetic piperazine compound that promotes different targets and signaling pathways of β2-adrenergic receptors mediating smooth muscle relaxation, and is a potential compound for the treatment of asthma and chronic obstructive bronchitis with anti-inflammatory activity.

AS1708727 is an orally bioavailable FOXO1 inhibitor that reduces plasma glucose and triglyceride levels in diabetic mice.

AS1907417 is a GPR119 agonist.

AS1928370 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).

AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.

AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic lamina and promoted IA and aortic di

ASN04421891, a potent GPR17 receptor modulator with an EC50 of 3.67 nM in the [35S]GTPγS binding assay, shows promise for neurodegenerative diseases research[1].

ASN06917370 (Compound V) is a specific modulator of the orphan receptor GPR17 (Uracil Nucleotide/Cysteinyl Leukotriene Receptor), with an EC50 of 268 pM for [35S]GTPyS binding, and exhibits neuroprotective effects.