T21432

Molindone ((±)-Molindone) is a therapeutic antipsychotic used to treat schizophrenia by blocking the action of dopamine in the brain. molindone is often used in combination with serotonin in a dose-dependent manner to increase errors and decrease response rates.

Averionol (Compound 26) is a flavonoid compound. It does not exhibit significant inhibitory activity against HIV integrase. However, Averionol can be utilized for research in the development of anti-HIV drugs.

CDK8-IN-20 (Compound 67j) is a highly selective and potent type I CDK8 inhibitor with oral bioavailability, exhibiting an IC50 value of 70.5 nM. The IC50 values for its action on homologous kinases CDK19, CDK7, and CDK9 are 147.8, 726.9, and 217.4 nM, respectively. CDK8-IN-20 effectively inhibits the proliferation of HCT-116, HT-29, and SW-480 cells with IC50 values of 5.9, 17.93, and 9.52 μM, respectively, while demonstrating low cytotoxicity toward normal gastric mucosal epithelial cells (GES-1) with an IC50 greater than 100 μM. It disrupts the Wnt/β-catenin pathway, downregulating β-catenin, Cyclin D1, and c-Myc expression. Additionally, CDK8-IN-20 induces reactive oxygen species (ROS) production and leads to G2/M phase and S phase cell cycle arrest. This compound is applicable in cancer research, such as colorectal cancer.

B-RafIN 20 (Compound Z-001) is a novel B-RAF inhibitor with an IC50 value of 37.80 nM. It binds to the DFG-out/C-helix-in conformation of the B-RAF kinase and exhibits anticancer activity against non-small cell lung cancer.

Aromatase-IN-7 (compound 75) is a potent and selective aromatase inhibitor with an IC50 of 5.78 nM, demonstrating efficacy comparable to Letrozole. It exhibits significant aromatase inhibitory activity both in vitro and in vivo. Aromatase-IN-7 is applicable for research in hormone-dependent breast cancer (HDBC).

Catechol diacetate (Compound 15) acts as an inhibitor of carbonic anhydrase (CA). It shows potential for research applications in glaucoma, epilepsy, edema, and cancer.

Lorglumide (CR-1409) is a potent cholecystokinin (CCK) receptor antagonist. It is employed in studies involving pancreatic secretion and growth.

THR-β modulator-3 (Compound 75-2) is a THR-β modulator that reduces total body fat and weight, and improves obesity.

α-Glucosidase-IN-107 (Compound 1) is an α-glucosidase inhibitor with an IC50 of 1.01 μM. It binds to an allosteric site on α-glucosidase and demonstrates no cytotoxicity to normal lung fibroblasts.

Asparaginate calcium is a calcium supplement that can enhance serum calcium levels.

Peplomycin (Bleomycin PEP) sulfate is an analog of Bleomycin and functions as an antitumor antibiotic. It exhibits strong antitumor activity with reduced pulmonary toxicity. Peplomycin sulfate can induce various skin abnormalities and apoptosis in oral squamous carcinoma SSCKN cells. Additionally, it is used to induce pulmonary fibrosis. Peplomycin sulfate is applicable in research related to tumors, pulmonary fibrosis, and other diseases.