T1786

Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antivirals to treat chronic hepatitis C. Elevations in serum enzyme levels during daclatasvir therapy are uncommon, and it has not been convincingly implicated in cases of clinically apparent liver injury with jaundice.

DSPE-PEG46-DBCO is a PEG-based linker for PROTACs, connecting two essential ligands to form PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DSPE-PEG46-Folate is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DSPE-PEG46-N3, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DSPE-PEG46-NH2 is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DSPE-PEG47-acid is a PEG-based linker for PROTACs, joining two essential ligands necessary for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

DSPE-PEG5-azide, a PEG-based linker for PROTACs, connects two essential ligands necessary for forming PROTAC molecules, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

DSPE-PEG5-propargyl is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. By leveraging the ubiquitin-proteasome system within cells, this linker enables selective protein degradation.

DSPE-PEG8-Mal is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].

cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER.