T1461

Candesartan (CV 11974) is an angiotensin II receptor blocker widely used in the treatment of hypertension and heart failure.

Biotin-PEG7-azide, a PEG-based linker for PROTACs, connects two essential ligands pivotal for PROTAC molecule formation, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Biotin-PEG8-alcohol is a PEG-based linker for PROTACs, joining two essential ligands and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Biotin-PFP ester, an alkyl/ether-based PROTAC linker, serves as a valuable component in the synthesis of PROTACs[1].

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50 values of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively, and exhibits neuroprotective effects [1].

Biperiden Hydrochloride (KL 373 Hydrochloride) is an anticholinergic antiparkinsonian agent that selectively blocks central M1 cholinoreceptors while exerting atropine-like effects on peripheral parasympathetic structures. Biperiden Hydrochloride is approved for the adjunctive treatment of postencephalitic, idiopathic, and arteriosclerotic Parkinson’s disease, demonstrates minimal impairment of novelty preference compared with other anticholinergics in comparative cognitive studies, and is associated with known adverse effects including drowsiness, vertigo, headache, and dizziness.

Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.

Biricodar is a P-glycoprotein and MRP-1 modulator.

Bis-aminooxy-PEG1 is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Bis-aminooxy-PEG2, a PEG-based linker for PROTACs, joins two essential ligands, crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-aminooxy-PEG3 is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules [Proteolysis-Targeting Chimeras]. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.