T1447

Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to deplete endogenous levels of serotonin.

Azido-PEG6-NHS ester is a cleavable 6-unit polyethylene glycol (PEG) linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1], and serves as a PEG- and alkyl/ether-based linker for the synthesis of proteolysis targeting chimeras (PROTACs)[2].

Azido-PEG6-PFP ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG7-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells (brackets).

Azido-PEG8-acid is a non-cleavable 8-unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Azido-PEG8-amine, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG7-amine is a non-cleavable ADC linker and PEG-based PROTAC linker that can be used to synthesise antibody-drug conjugates (ADCs) and PROTACs. It can undergo click chemistry reactions with molecules containing alkyne, DBCO or BCN groups.

Azido-PEG8-Boc is a polyethylene glycol (PEG) and alkyl/ether-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Azido-PEG8-C1-NHS ester is a polyethylene glycol (PEG)-based linker designed for synthesizing proteolysis targeting chimeras (PROTACs)[1].

Azido-PEG8-CH2COO-PFP is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG8-NHS ester is an 8 unit PEG linker with cleavable properties, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also serves as a PEG- and Alkyl/ether-based PROTAC linker, enabling its utilization in the synthesis of PROTACs[2].