T1445

Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.

Azido-PEG4-hydrazide is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Azido-PEG4-NHS-ester is a PEG-based linker for PROTACs, joining two essential ligands and facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Azido-PEG4-tetra-Ac-beta-D-glucose is a polyethylene glycol (PEG)-based PROTAC linker used for PROTAC synthesis[1].

Azido-PEG4-Val-Cit-PAB-OH is a 4-unit PEG ADC linker and a PEG-based PROTAC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2].

Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as the conjugate CPT-APO (CPT: Camptothecin.

Azido-PEG5-Ala-Ala-Asn-PAB is a cleavable 5-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Azido-PEG5-alcohol, a non-cleavable 5 unit polyethylene glycol (PEG) ADC linker, finds application in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, it serves as a PEG-based PROTAC linker for the synthesis of PROTACs[2].

Azido-PEG5-amine is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Azido-PEG5-Boc, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules and facilitates selective protein degradation via the ubiquitin-proteasome system within cells.

Azido-PEG5-CH2CO2-NHS is a PEG-based linker for PROTACs that bonds two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.