T1219

Sisomicin Sulfate (Pathomycin) is the sulfate salt form of sisomicin, a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. Sisomicin is structurally similar to gentamicin but has a unique unsaturated diamino sugar. Of the aminoglycoside antibiotics, sisomicin has the greatest activity against gram-positive bacteria.

Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).

NBTGR is a potent nucleoside transport inhibitor(adenosine uptake ,Ki of 70 nM).

NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies.

NCGC00247743 is an inhibitor of histone lysine demethylase KDM4.

NCGC00249987 is a highly selective, allosteric inhibitor of Eya2 Tyr phosphatase activity, affecting Eya2 ED and MBP-Eya2 FL with IC50 values of 3 μM and 6.9 μM, respectively.

NCI172112 is is used to develop antitumor agents effective against CNS tumors.

NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, and >57 μM, respectively.

NCT-506 is an orally bioavailable inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), with an IC50 of 7 nM.

NCX899 shows inhibitory activity against angiotensin-converting enzyme (ACE) activity.

NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.

NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.