T1146

Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

GPR84 antagonist 8 is a selective GPR84 antagonist applicable for investigating inflammatory and fibrotic diseases.

GSK-3 inhibitor 1 is a GSK-3 inhibitor.

GSK-3484862 is a non-covalent Dnmt1 inhibitor that induces DNA hypomethylation, offering potential therapeutic benefits against cancer.

GPR4 antagonist 1 is a GPR4 antagonist with an IC50 of 189 nM.

NE 52-QQ57 is a selective, orally available antagonist of GPR4 (IC50: 70 nM) with anti-inflammatory activity.

GR 103691, a potent and selective dopamine D3 receptor antagonist (Ki: 0.4 nM), exhibits more than 100-fold selectivity for human dopamine D3 receptors over human D4 and D1 sites.

GRL0617 is a selective and competitive noncovalent inhibitor of SARS-CoVPLpro and deubiquitinase (IC50: 0.6 μM, Ki: 0.49 μM).

Lenacapavir (GS-6207) is the first HIV-1 capsid inhibitor approved by the U.S. Food and Drug Administration, the European Medicines Agency, and Health Canada for the treatment of MDR HIV-1 infection.[3]

GSK-2793660 is an orally active and irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 is a bioactive dipeptide that can be used for the research of bronchiectasis [1] [2].

GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.

Nifedipine-D6 is deuterium labeled nifedipine (T1146) which is a potent blocker of calcium channel.

Nifedipine-13C8 is a deuterium-labeled form of Nifedipine. Nifedipine (T1146) (BAY-a-1040) acts as an effective calcium channel blocker, frequently utilized in studies related to myocardial dysfunction.

Nifedipine-D4 is the deuterated form of Nifedipine. Nifedipine (T1146) (BAY-a-1040) is a potent calcium channel blocker widely used in studies related to myocardial dysfunction.