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Search Result

Search Results for " smoothened "

Targets

Hedgehog/Smoothened Hedgehog/Smoothened Smo

52

Compounds

4

Natural Products

7

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1779 SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist Hedgehog/Smoothened , Smo
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.
T4211 SAG hydrochloride (912545-86-9(free base)) Smoothened Agonist HCl Hedgehog/Smoothened
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
T3460 HhAntag Hedgehog/Smoothened , Smo
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.
T22814 GSA-10 Hedgehog/Smoothened
Smoothened (Smo) receptor agonist
T12109 MRT-83 Smo
MRT-83 is a potent Smo antagonist.
T14188 ALLO-2 Hedgehog/Smoothened , Smo
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
T2450 SANT-1 SANT 1 Hedgehog/Smoothened , Smo
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T6891 MK-4101 Apoptosis , Hedgehog/Smoothened , Smo
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells.
T9531 MRT-14 Smo
MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.
T6514 Glasdegib PF-04449913 Hedgehog/Smoothened , Smo
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T2666 Taladegib LY2940680 Hedgehog/Smoothened , Smo
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
T1810 Purmorphamine Shh Signaling Antagonist VI Hedgehog/Smoothened , Smo , Autophagy
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
T24159 IHR-1 IHR 1 Smo
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
T11838 LEQ506 NVP-LEQ506 Smo
LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
T9532 MRT-81 Others
MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance...
T5465 PF-5274857 PF-5274857 freebase Smo
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t...
T2299 BMS-833923 XL-139 Apoptosis , Hedgehog/Smoothened , Smo
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
T23027 MRT-10 Hedgehog/Smoothened
MRT-10 is a Smoothened (Smo) receptor antagonist.
T1926 Sonidegib Erismodegib,NVP-LDE225,LDE225 Hedgehog/Smoothened , Smo
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T0107 Halcinonide Halcimat,Halciderm,Halcinonida,SQ-18566 Glucocorticoid Receptor , Smo
Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
T2250 DY131 DY 131,GSK 9089,DY-131 Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Smo
DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ.
T15727 Sonidegib diphosphate NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate Smo
Sonidegib diphosphate (LDE225 diphosphate) is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively).
T23370 SMANT hydrochloride N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride,hydrochloride,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide;hydrochloride,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide,SMANT HCl,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride Hedgehog/Smoothened
SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.
T15019 CUR61414 Hedgehog/Smoothened
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
T40465 SAG dihydrochloride Hedgehog/Smoothened
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo.
T63429 SMO-IN-2 Hedgehog/Smoothened
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c...
T15019L CUR61414 hydrochloride CUR61414 hydrochloride (334998-36-6 Free base) Hedgehog/Smoothened
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively...
T64351 GI-560192 RL-0070933 Smo
GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway.
T24754 Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5 Hedgehog/Smoothened
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...
T70178 Sonidegib metabolite M25
Sonidegib metabolite M25 is a smoothened (SMO) antagonist.
T22958 M 25 Others
M 25 is a Smoothened (Smo) receptor antagonist.
T26723 AZD8542 AZD-8542,AZD 8542
AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.
T16843 Saridegib IPI-926,Patidegib Others
Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway.
T71299 M-25
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.
T23307 SANT 2 SANT-2 Others
SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM).
T24400 LEQ-506 HCl (1204975-42-7 free base) LEQ-506,LEQ-506 dihychloride,NPVLEQ 506,LEQ506,LEQ-506 HCl,LEQ 506
LEQ506 is an orally bioavailable small-molecule Smoothened antagonist. It also has a potential antineoplastic activity.
T71520 LEQ-506
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand ce...
T61895 AZD7254
AZD7254 is an oral effective Smoothened (SMO) inhibitor, and the EC50 of sonic Hh protein (shh) is 1.0 nM.
T61897 SMO-IN-1
SMO-IN-1 (Compound 15) is an oral effective Smoothened (SMO) inhibitor. The EC50 value of sonic Hh protein (shh) is 89 nM.
T25918 Palmitoyl-L-aspartic acid L-N-Palmitoylaspartic acid
Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid rec...
T63387 SMO-IN-3
SMO-IN-3 is a potent inhibitor of smoothened (SMO) that acts on the hedgehog (Hh) signaling pathway (IC50: 34.09 nM). SMO-IN-3 inhibits the proliferation of Daoy, a human medulloblastoma cell line, and exhibits anticance...
T38767 MRT-83 hydrochloride
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in t...
T62772 TPB15
TPB15 is an orally active inhibitor of Hh (Hedgehog) signalling. TPB15 significantly blocks the MDA-MB-468 cell cycle and induces apoptosis. TPB15 blocks Smo (Smoothened) translocation into cilia and reduces Smo protein ...
T35537 Hedgehog Antagonist VIII
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcript...
T70693 MRT-92 HCl salt
MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell prolifera...
T35539 IHR-Cy3 IHR-Cy3
Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog also available. Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Ch...
T35538 HPI-1 (hydrate) HPI-1 hydrate
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss o...
T36910 PF 04449913 maleate
Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discov...
T70195 NL-103
NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibito...
T35558 KAAD-Cyclopamine
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc...

Compounds

SAG
T1779
Synonym: Smoothened Agonist (SAG) HCl,Smoothened Agonist
Target: Hedgehog/Smoothened, Smo
SAG hydrochloride (912545-86-9(free base))
T4211
Synonym: Smoothened Agonist HCl
Target: Hedgehog/Smoothened
HhAntag
T3460
Synonym:
Target: Hedgehog/Smoothened, Smo
GSA-10
T22814
Synonym:
Target: Hedgehog/Smoothened
MRT-83
T12109
Synonym:
Target: Smo
ALLO-2
T14188
Synonym:
Target: Hedgehog/Smoothened, Smo
SANT-1
T2450
Synonym: SANT 1
Target: Hedgehog/Smoothened, Smo
MK-4101
T6891
Synonym:
Target: Apoptosis, Hedgehog/Smoothened, Smo
MRT-14
T9531
Synonym:
Target: Smo
Glasdegib
T6514
Synonym: PF-04449913
Target: Hedgehog/Smoothened, Smo
Taladegib
T2666
Synonym: LY2940680
Target: Hedgehog/Smoothened, Smo
Purmorphamine
T1810
Synonym: Shh Signaling Antagonist VI
Target: Hedgehog/Smoothened, Smo, Autophagy
IHR-1
T24159
Synonym: IHR 1
Target: Smo
LEQ506
T11838
Synonym: NVP-LEQ506
Target: Smo
MRT-81
T9532
Synonym:
Target: Others
PF-5274857
T5465
Synonym: PF-5274857 freebase
Target: Smo
BMS-833923
T2299
Synonym: XL-139
Target: Apoptosis, Hedgehog/Smoothened, Smo
MRT-10
T23027
Synonym:
Target: Hedgehog/Smoothened
Sonidegib
T1926
Synonym: Erismodegib,NVP-LDE225,LDE225
Target: Hedgehog/Smoothened, Smo
Halcinonide
T0107
Synonym: Halcimat,Halciderm,Halcinonida,SQ-18566
Target: Glucocorticoid Receptor, Smo
DY131
T2250
Synonym: DY 131,GSK 9089,DY-131
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Smo
Sonidegib diphosphate
T15727
Synonym: NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate
Target: Smo
SMANT hydrochloride
T23370
Synonym: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride,hydrochloride,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide;hydrochloride,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide,SMANT HCl,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride
Target: Hedgehog/Smoothened
CUR61414
T15019
Synonym:
Target: Hedgehog/Smoothened
SAG dihydrochloride
T40465
Synonym:
Target: Hedgehog/Smoothened
SMO-IN-2
T63429
Synonym:
Target: Hedgehog/Smoothened
CUR61414 hydrochloride
T15019L
Synonym: CUR61414 hydrochloride (334998-36-6 Free base)
Target: Hedgehog/Smoothened
GI-560192
T64351
Synonym: RL-0070933
Target: Smo
Hh-Ag1.5
T24754
Synonym: SAG-1.5,SAG1.5,SAG 1.5
Target: Hedgehog/Smoothened
Sonidegib metabolite M25
T70178
Synonym:
Target:
M 25
T22958
Synonym:
Target: Others
AZD8542
T26723
Synonym: AZD-8542,AZD 8542
Target:
Saridegib
T16843
Synonym: IPI-926,Patidegib
Target: Others
M-25
T71299
Synonym:
Target:
SANT 2
T23307
Synonym: SANT-2
Target: Others
LEQ-506 HCl (1204975-42-7 free base)
T24400
Synonym: LEQ-506,LEQ-506 dihychloride,NPVLEQ 506,LEQ506,LEQ-506 HCl,LEQ 506
Target:
LEQ-506
T71520
Synonym:
Target:
AZD7254
T61895
Synonym:
Target:
SMO-IN-1
T61897
Synonym:
Target:
Palmitoyl-L-aspartic acid
T25918
Synonym: L-N-Palmitoylaspartic acid
Target:
SMO-IN-3
T63387
Synonym:
Target:
MRT-83 hydrochloride
T38767
Synonym:
Target:
TPB15
T62772
Synonym:
Target:
Hedgehog Antagonist VIII
T35537
Synonym:
Target:
MRT-92 HCl salt
T70693
Synonym:
Target:
IHR-Cy3
T35539
Synonym: IHR-Cy3
Target:
HPI-1 (hydrate)
T35538
Synonym: HPI-1 hydrate
Target:
PF 04449913 maleate
T36910
Synonym:
Target:
NL-103
T70195
Synonym:
Target:
KAAD-Cyclopamine
T35558
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T2825 Cyclopamine 11-Deoxojervine Hedgehog/Smoothened , Endogenous Metabolite , Smo
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T3363 Jervine Iervin,11-Ketocyclopamine,Jerwiny Hedgehog/Smoothened , Smo
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signa...
T3912 Saikosaponin B1 Others
Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.
T10085 20(S)-Hydroxycholesterol 20α-Hydroxycholesterol Smo
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo).

Natural Products

Cyclopamine
T2825
Synonym: 11-Deoxojervine
Target: Hedgehog/Smoothened, Endogenous Metabolite, Smo
Jervine
T3363
Synonym: Iervin,11-Ketocyclopamine,Jerwiny
Target: Hedgehog/Smoothened, Smo
Saikosaponin B1
T3912
Synonym:
Target: Others
20(S)-Hydroxycholesterol
T10085
Synonym: 20α-Hydroxycholesterol
Target: Smo

Recombinant Proteins

Species：
Human (5)
Mouse (2)
Expression System：
E. coli (4)
HEK293 (3)
Tag：
His (3)
None (2)
N-terminal 6xHis-SUMO-tagged (1)
N-terminal 6xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPY-03345 Sonic Hedgehog Protein, Mouse, Recombinant (His) Mouse HEK293
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha...
TMPH-01528 IHH Protein, Human, Recombinant (His) Human E. coli
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target gen...
TMPY-02832 Sonic Hedgehog Protein, Human, Recombinant (aa 198-462, His) Human HEK293
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha...
TMPY-02905 Sonic Hedgehog Protein, Human, Recombinant (aa 1-197, His) Human HEK293
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha...
TMPH-02540 GRK2 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to...
TMPJ-01128 SHH Protein, Human, Recombinant (C24II) Human E. coli
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic...
TMPJ-01127 SHH Protein, Human, Recombinant Human E. coli
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic...
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