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PKUMDL-LC-101-D04

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PKUMDL-LC-101-D04
GPX4-Activator-1d4, PKUMDL-LC-101-D04
T369352143896-83-5
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4- -, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.
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6-8 weeks
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