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Search Result

Search Results for " mt2 "

Targets

Melatonin Receptor MT Receptor

25

Compounds

1

Natural Products

7

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1463 Ramelteon TAK-375 Melatonin Receptor , MT Receptor
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
T3495 Tasimelteon VEC-162,BMS-214778 Melatonin Receptor , MT Receptor
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
T1445 Agomelatine Thymanax,S-20098,Valdoxan Melatonin Receptor , 5-HT Receptor
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
T16834 S26131 N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide MT Receptor
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively.
T11167 EHMT2-IN-2 Others
EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.
T11166 EHMT2-IN-1 Others
EHMT2-IN-1 is a potent EHMT inhibitor, . Used in the research of blood disorder or cancer.with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.
T10198 8-M-PDOT 8-Methoxy-2-propionamidotetralin,AH-002 MT Receptor
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to study MT2-induced neuropathic pain.
T9193 ACH-000143 Melatonin Receptor , MT Receptor
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T15795 Luzindole N-0774 Melatonin Receptor , MT Receptor
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...
T22530 6-Chloromelatonin Melatonin Receptor , Dopamine Receptor
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]...
T14042 4-P-PDOT 4-phenyl-2- propionamidotetralin Melatonin Receptor , MT Receptor
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
T10073 2-Iodomelatonin Melatonin Receptor
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin bind...
T34081 Piromelatine NEU-P-11,NEU-P 11,NEU-P11 P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ...
T60523 Agomelatine hydrochloride S-20098 hydrochloride MT Receptor
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, r...
T22721 DH97 DH 97 Others
MT2 melatonin receptor antagonist
T69409 DH-97
DH-97 is a potent MT2 melatonin receptor antagonist (pKi value = 8.03).
T17095 TIK-301 PD-6735,LY-156735 5-HT Receptor
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an...
T10266 Agomelatine-d6 Agomelatine D6,S-20098 D6 Others
Agomelatine D6 (S-20098 D6) is a deuterium-labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors.
T10193 7-Desmethyl-agomelatine Others
7-Desmethyl-agomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.
T10192 7-Desmethyl-3-hydroxyagomelatine 3-Hydroxy-7-desmethyl agomelatine 5-HT Receptor
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.
T60490 Melatonin receptor agonist 1
Melatonin receptor agonist 1 (compound 20c) is a potent agonist of melatonin receptor (MT) with Ki values of 108 nM for MT2 and 1140 nM for MT 1 [1].
T10267 Agomelatine (L(+)-Tartaric acid) S-20098 L(+)-Tartaric acid 5-HT Receptor
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonis...
T70035 Tasimelteon-d5
Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ...
T12689 Ramelteon metabolite M-II Others
Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin.
T28645 S-22153
S22153 is an antagonist of melatonin receptor.

Compounds

Ramelteon
T1463
Synonym: TAK-375
Target: Melatonin Receptor, MT Receptor
Tasimelteon
T3495
Synonym: VEC-162,BMS-214778
Target: Melatonin Receptor, MT Receptor
Agomelatine
T1445
Synonym: Thymanax,S-20098,Valdoxan
Target: Melatonin Receptor, 5-HT Receptor
S26131
T16834
Synonym: N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide
Target: MT Receptor
EHMT2-IN-2
T11167
Synonym:
Target: Others
EHMT2-IN-1
T11166
Synonym:
Target: Others
8-M-PDOT
T10198
Synonym: 8-Methoxy-2-propionamidotetralin,AH-002
Target: MT Receptor
ACH-000143
T9193
Synonym:
Target: Melatonin Receptor, MT Receptor
Luzindole
T15795
Synonym: N-0774
Target: Melatonin Receptor, MT Receptor
6-Chloromelatonin
T22530
Synonym:
Target: Melatonin Receptor, Dopamine Receptor
4-P-PDOT
T14042
Synonym: 4-phenyl-2- propionamidotetralin
Target: Melatonin Receptor, MT Receptor
2-Iodomelatonin
T10073
Synonym:
Target: Melatonin Receptor
Piromelatine
T34081
Synonym: NEU-P-11,NEU-P 11,NEU-P11
Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel
Agomelatine hydrochloride
T60523
Synonym: S-20098 hydrochloride
Target: MT Receptor
DH97
T22721
Synonym: DH 97
Target: Others
DH-97
T69409
Synonym:
Target:
TIK-301
T17095
Synonym: PD-6735,LY-156735
Target: 5-HT Receptor
Agomelatine-d6
T10266
Synonym: Agomelatine D6,S-20098 D6
Target: Others
7-Desmethyl-agomelatine
T10193
Synonym:
Target: Others
7-Desmethyl-3-hydroxyagomelatine
T10192
Synonym: 3-Hydroxy-7-desmethyl agomelatine
Target: 5-HT Receptor
Melatonin receptor agonist 1
T60490
Synonym:
Target:
Agomelatine (L(+)-Tartaric acid)
T10267
Synonym: S-20098 L(+)-Tartaric acid
Target: 5-HT Receptor
Tasimelteon-d5
T70035
Synonym:
Target:
Ramelteon metabolite M-II
T12689
Synonym:
Target: Others
S-22153
T28645
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2O2728 Glycine 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll MT Receptor , Endogenous Metabolite , iGluR
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

Natural Products

glycine
T2O2728
Synonym: 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll
Target: MT Receptor, Endogenous Metabolite, iGluR

Recombinant Proteins

Species：
Human (4)
Mouse (1)
Mycobacterium tuberculosis (1)
Rat (1)
Expression System：
E. coli (4)
Yeast (2)
Baculovirus-Insect Cells (1)
Tag：
N-terminal 6xHis-tagged (2)
C-terminal 6xHis-tagged (1)
GST (1)
His (1)
N-terminal 10xHis-tagged (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPY-01306 DNMT2 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
DNMT2, also known as tRNA (cytosine-5-)-methyltransferase, DNA methyltransferase homolog HsaIIP, and TRDMT1, is a member of the DNA methyltransferase family of enzymes. DNMT2 enzymes have been widely conserved during evo...
TMPH-01668 MT2A Protein, Human, Recombinant (His) Human Yeast
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
TMPH-02635 EEF1AKMT2 Protein, Mouse, Recombinant (His) Mouse E. coli
Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.
TMPY-04763 CKMT2 Protein, Rat, Recombinant (His) Rat E. coli
CKMT2 Protein, Rat, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 45.6 kDa. Accession number: B0BNC0
TMPH-01526 KMT2E Protein, Human, Recombinant (His & Myc) Human E. coli
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4'...
TMPH-01331 FERMT2 Protein, Human, Recombinant (His) Human E. coli
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesio...
TMPH-03001 MT2731 Protein, Mycobacterium tuberculosis, Recombinant (His) Mycobacterium tuberculosis Yeast
Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin MT2730.
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