ML 9

ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 μM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) acti

ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.

(±)9(10)-DiHOME-D4, Concentration: 100 µg/mL (Standard) is a reference standard of (±)9 (10)-DiHOME-[D4] intended for quantitative analysis, quality control, and related biochemical research applications.

(±)9,10-EpOME-D4, Concentration: 100 µg/mL (Standard) is a reference standard of (±)9,10-EpOME-[D4] intended for quantitative analysis, quality control, and related biochemical research applications.

Chenodeoxycholic Acid-[D9] (Standard) is a reference standard of Chenodeoxycholic Acid-[D9] intended for quantitative analysis, quality control, and related biochemical research applications.

Glycochenodeoxycholic Acid-[D9] (Standard) is a reference standard of Glycochenodeoxycholic Acid-[D9] intended for quantitative analysis, quality control, and related biochemical research applications.

Taurochenodeoxycholic Acid-[D9] Sodium Salt (Solution) (Standard) is a reference standard of Taurochenodeoxycholic Acid-[D9] Sodium Salt (Solution) intended for quantitative analysis, quality control, and related biochemical research applications.

18-Hydroxycorticosterone-D4 (Standard) is a reference standard of 18-Hydroxycorticosterone-D4 intended for quantitative analysis, quality control, and related biochemical research applications. 18-Hydroxycorticosterone-d4 is a deuterated compound of 18-Hydroxycorticosterone. 18-Hydroxycorticosterone has a CAS number of 561-65-9. 18-Hydroxycorticosterone is a corticosteroid and corticosterone derivative, which can lead to serious electrolyte imbalances.

[S5K, F6Y, L9mL, M10Mox] neurokinin A (4–10) is a neuropeptide A analogue and peptide fragment. It exhibits high selectivity for the NK1R on both mouse and human tachykinin receptors, with a half-life of 10.3 hours in mice.

ML-93 is an orally active SAE inhibitor with an IC50 value of 0.4 μM. It effectively inhibits the SUMOylation pathway in HCT116 cells and demonstrates potent antitumor activity in HCT116 colorectal cancer xenograft models. ML-93 is applicable in colorectal cancer research.

ML901 is an antimalarial compound with an IC50 value of 2 nM against Plasmodium parasites. It functions by selectively inhibiting Plasmodium falciparum tyrosine tRNA synthetase (PfYRS) through a "reaction hijacking" mechanism. ML901 demonstrates full life-cycle killing activity in mouse models of malaria and can be used for studying Plasmodium infections.

2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg/ml, respectively).12-Hydroxyanthraquinone (19 μM) induces estrogen receptor α (ERα) activation in a yeast two-hybrid assay.2 1.Luo, Y., Shen, H.-Y., Shen, Q.-X., et al.A new anthraquinone and a new naphthoquinone from the whole plant of Spermacoce latifoliJ. Asian Nat. Prod. Res.19(9)869-876(2017) 2.Kurihara, R., Shiraishi, F., Tanaka, N., et al.Presence and estrogenicity of anthracene derivatives in coastal Japanese watersEnviron. Toxicol. Chem.24(8)1984-1993(2005)

CYP51-IN-9 (compound 1i) is an analog of Fluconazole and serves as an effective antifungal agent. It exhibits a MIC80 of 62.5 ng/mL against Microsporum gypseum and Candida albicans, indicating potent inhibitory activity.

Antiviralagent 65 (compound 9) is an antiviral agent targeting the H1N1 influenza virus, with an EC50 of 7 μg/mL.

InhA-IN-9 (compound 7h) is an inhibitor of the Mycobacterium tuberculosis enzyme InhA (an enoyl ACP reductase). It has the ability to bind with InhA and demonstrates anti-tuberculosis activity with a MIC value of 2 μg/mL.

ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.

Succinate dehydrogenase-IN-9 (Compound Iik) is an inhibitor of succinate dehydrogenase with an IC50 of 3.6 μM. It demonstrates strong inhibitory activity against various fungi, such as S. sclerotiorum, with an EC50 of 1.14 μg/mL. Additionally, Succinate dehydrogenase-IN-9 enhances nitrate reductase activity, promoting plant growth.

3-O-methyl Estradiol is a synthetic estrogen known for its ability to interfere with microtubule networks in V79 Chinese hamster cells, with an EC50 value of 9 µM. At a concentration of 20 µM, it inhibits the proliferation of these cells by 92%. Additionally, when male rats on a high-cholesterol diet are administered 3-O-methyl Estradiol (25 mg in a 0.2 ml solution, p.o.), it results in decreased serum cholesterol levels and increases body weight loss, suggesting feminizing effects. It has also been utilized as a standard for quantifying 17β-estradiol in hen urine.

Anti-MRSA agent 9 (compound 39) exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) isolated from clinical samples, with a minimum inhibitory concentration (MIC) of 1 μg/ml. Additionally, Anti-MRSA agent 9 demonstrates anti-MRSA efficacy in vivo.

AR Degrader-1 (Compound ML 2-9) is a monovalent degrader of androgen receptors (AR) categorized under molecular glues. In LNCaP prostate cancer cells, it facilitates AR degradation through DCAF16 (E3 ligase) while exhibiting minimal cytotoxicity.

Antibiofilm agent-7 (Compound 9) demonstrates significant antibiofilm activity with IC50 values of 60 µg/mL, 133.32 µg/mL, and 19.67 µg/mL against Staphylococcus aureus, Escherichia coli, and methicillin-resistant Staphylococcus aureus (MRSA), respectively. It also exhibits antimicrobial activity with MIC values of 4.88 µg/mL, 78.13 µg/mL, 9.77 µg/mL, and 39.06 µg/mL against Staphylococcus aureus, Escherichia coli, Candida albicans, and MRSA, respectively.

MMP-9-IN-11 (compound 77) is a potent MMP-9 inhibitor. It exhibits significant cytotoxic activity against A549 and L929 cell lines, with IC50 values of 4.04 and 13.97 μg/mL, respectively.

Antileishmanial agent-34 (Fig. (9), compound 3) is an aurone with activity against Leishmania parasites. It is effective against extracellular forms Lmaj, Ldon, Linf, and Lenr, as well as the intracellular form of Ldon (IC50 < 2 µg/mL).

SDH-IN-33 (Compound I-9) is a succinate dehydrogenase inhibitor demonstrating excellent antifungal activity with an EC50 of 0.07 μg/mL. It effectively inhibits Rhizoctonia solani succinate dehydrogenase (RsSDH), with an IC50 of 0.35 μg/mL. SDH-IN-33 is applicable for studies on fungal infections.