lrrk2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11878	LRRK2 inhibitor 1		LRRK2 , CDK
	LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.		LRRK2 , CDK
T2246	LRRK2-IN-1		Apoptosis , LRRK2 , CDK
	LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.		Apoptosis , LRRK2 , CDK
T63620	LRRK2-IN-3
	LRRK2-IN-3 is a potent, selective, orally active LRRK2 inhibitor that crosses the blood-brain barrier with an IC50 value of 0.6 nM in hPBMCs. LRRK2-IN-3 can be used to study Parkinson's disease.
T63824	LRRK2-IN-2
	LRRK2-IN-2 is a selective, potent, and orally active LRRK2 inhibitor (IC50: 0.6 nM) that crosses the blood-brain barrier. LRRK2-IN-2 can be used to study Parkinson's disease.
T63621	LRRK2-IN-4
	LRRK2-IN-4 is a potent, selective, orally active, leucine-rich repeat kinase 2 (LRRK2) inhibitor that crosses the blood-brain barrier with an IC50 value of 2.6 nM. LRRK2-IN-3 has shown investigational potential in Parkin...
T62871	LRRK2-IN-6
	LRRK2-IN-6 (compound 22) is an orally active, selective leucine-rich repeat protein kinase 2 gene (LRRK2) inhibitor with blood-brain barrier permeability that inhibits GS LRRK2 (IC50: 4.6 μM) and WT LRRK2 (IC50: 49 μM). ...
T63057	LRRK2-IN-5
	LRRK2-IN-5 (compound 25) is an oral active, blood-brain barrier penetrating, selective leucine-rich repeat protein kinase 2 (LRRK2) inhibitor, which is effective for GS LRRK2 (IC50: 1.2 μM) and WT LRRK2 (IC50:16 μM) had ...
T79746	LRRK2-IN-10		LRRK2
	LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS935 and 5.2 nM for G2019S-LRRK2 pS1292. It holds promise for...		LRRK2
T73176	LRRK2-IN-7
	LRRK2-IN-7 is a potent LRRK2 kinase inhibitor that demonstrates high selectivity and central nervous system (CNS) penetration, possessing an IC50 value of 0.9 nM. It exhibits more than 1000-fold selectivity against a bro...
T72421	LRRK2/NUAK1/TYK2-IN-1
	LRRK2/NUAK1/TYK2-IN-1 (compound 226) exhibits inhibitory activity against LRRK2 (Wt), LRRK2 (G2019), TYK2, and NUAK1, demonstrating IC50 values below 10 nM. This compound is useful for research into autoimmune diseases.
T7155	JH-II-127		LRRK2
	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),		LRRK2
T7729	PF-06454589		LRRK2
	PF-06454589 is a potent inhibitor of LRRK2.		LRRK2
T1770	GNE-9605		LRRK2
	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).		LRRK2
T2022	CZC-54252	CZC54252,CZC 54252	LRRK2
	CZC-54252 is a potent inhibitor of LRRK2.		LRRK2
T5139	CZC-25146 hydrochloride		LRRK2
	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.		LRRK2
T39202	CZC-54252 hydrochloride		LRRK2
	CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human...		LRRK2
T3053	CZC-25146	CHEMBL2397014	LRRK2
	CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.		LRRK2
T16115	MLi-2		LRRK2
	MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a ce...		LRRK2
T2050	PF-06447475		LRRK2
	PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.		LRRK2
T39972	EB-42486		LRRK2
	EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.		LRRK2
T1945	GNE-7915	GNE7915	LRRK2
	GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.		LRRK2
T16512	PFE-360	PF-06685360	LRRK2
	PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).		LRRK2
T6031	GNE0877	GNE 0877,GNE-0877	LRRK2
	GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).		LRRK2
T6176	IKK 16	IKK Inhibitor VII,IKK-16,IKK16	IκB/IKK , LRRK2
	IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.		IκB/IKK , LRRK2
T2240	GSK2578215A		Mitophagy , LRRK2 , Autophagy
	GSK2578215A is a potent and selective LRRK2 kinase inhibitor.		Mitophagy , LRRK2 , Autophagy
T7196	HG-10-102-01		LRRK2
	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).		LRRK2
T5184	ERK5-IN-1		ERK
	ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).		ERK
T6057	URMC-099		ROCK , MLK , VEGFR , SGK , DNA Alkylation , Trk receptor , c-Met/HGFR , LRRK2 , MEK , IGF-1R , Syk , Bcr-Abl , CDK , Src , Aurora Kinase , Autophagy
	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
T2014	CCG-1423	CCG1423	LRRK2 , Rho , Ras
	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.		LRRK2 , Rho , Ras
T74638	XL01126
	XL01126, a potent degrader of LRRK2, exhibits DC50 values of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. It has the ability to cross the blood-brain barrier, making it a viable degrader probe for Parkinson’s...
T34706	SRI-29132	SRI29132,SRI 29132,TPZ-11,TPZ 11,TPZ11
	SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction ph...
T15557	IKK 16 hydrochloride		Others
	IKK 16 hydrochloride is a selective IKK2, IKK complex, and IKK1 IκB kinase (IKK) inhibitor (IC50s: 40 nM, 70 nM and 200 nM, respectively). IKK16 inhibits leucine-rich repeat kinase-2 (LRRK2; IC50: 50 nM).		Others
T70338	Lu AF58786
	Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively.
T73846	PF-06456384 trihydrochloride
	PF-06447475 trihydrochloride is a potent, selective LRRK2 kinase inhibitor that demonstrates excellent brain penetration, exhibiting IC50 values of 3 nM for wild-type LRRK2 and 11 nM for G2019S LRRK2 variants. It holds p...
T83737	LRRKtide TFA	Moesin (550-564),Membrane-organizing Extension Spike Protein (550-564)
	LRRKtide, a peptide substrate for leucine-rich repeat kinase 2 (LRRK2)—an enzyme often mutated in Parkinson's disease patients—corresponds to amino acids 550-564 of the membrane-organizing extension spike protein (moesin...
T70363	PF-06371900
	PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).
T72640	GNE-7915 tosylate
	GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.
T79351	JH-XII-03-02		PROTACs
	JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PD) research [1].		PROTACs
T81785	MK-1468		LRRK2
	MK-1468, a highly selective and brain-penetrant LRRK2 inhibitor, exhibits an IC50 of 0.8 nM and is utilized in the study of Parkinson's disease [1].		LRRK2
T61527	GSK2646264
	GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. In addition to targeting SYK, GSK2646264 also inhibits several other kinases, including LCK, LRRK...
T72999	PF-06455943
	PF-06455943, a leucine rich repeat kinase 2 (LRRK2) inhibitor, exhibits an inhibition concentration (IC50) value of 3 nM and also functions as a PET radioligand. It is utilized in the research of ADME/neuro PK characteri...
T5428	BIX 02565		LRRK2 , S6 Kinase
	BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).		LRRK2 , S6 Kinase

Compounds

LRRK2 inhibitor 1

T11878

Target: Apoptosis, LRRK2, CDK

LRRK2/NUAK1/TYK2-IN-1

Synonym: CZC54252,CZC 54252

Target: LRRK2

CZC-25146 hydrochloride

T5139

Synonym:

Target: LRRK2

CZC-54252 hydrochloride

Synonym: CHEMBL2397014

Synonym: GNE 0877,GNE-0877

Target: LRRK2

IKK 16

T6176

Synonym: IKK Inhibitor VII,IKK-16,IKK16

Target: IκB/IKK, LRRK2

GSK2578215A

T2240

Synonym:

Target: Mitophagy, LRRK2, Autophagy

Target: ROCK, MLK, VEGFR, SGK, DNA Alkylation, Trk receptor, c-Met/HGFR, LRRK2, MEK, IGF-1R, Syk, Bcr-Abl, CDK, Src, Aurora Kinase, Autophagy

CCG-1423

T2014

Synonym: CCG1423

Target: LRRK2, Rho, Ras

Synonym: SRI29132,SRI 29132,TPZ-11,TPZ 11,TPZ11

PF-06456384 trihydrochloride

Synonym: Moesin (550-564),Membrane-organizing Extension Spike Protein (550-564)

Target: LRRK2, S6 Kinase

Cat No.	Product Name	Species	Expression System
TMPH-02873	RAB10 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou...

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Recombinant Proteins