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Search Results for " ht-29 "

Targets

50

Compounds

20

Natural Products

Cat No. Product Name Synonyms Targets
T8796 CAN508 CDK
CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50...
T9696 β-catenin-IN-2 Wnt/beta-catenin
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
T8745 PROTAC BRAF-V600E degrader-1 Compound 23 Raf
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
T9079 Apostatin-1 Apt-1 Others
Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.
T5858 Sertindole Lu 23-174 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T4327 Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 Apoptosis , Chk , S6 Kinase
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.
T4310 Prexasertib LY2606368 Apoptosis , Chk
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
T23386 SR 142948 Neurotensin Receptor
SR 142948 is a neurotensin (NT) receptor antagonist.
T9448 IL-17A inhibitor 1 IL Receptor
IL-17A inhibitor 1 is a IL-17A inhibitor with IC50 of <9.45 nM in alphalisa assay. IL-17A inhibitor 1 inhibits HT-29 cells with IC50 of 9.3 nM.
T9051 ZYN57939 MTR-106 DNA/RNA Synthesis
ZYN57939 (MTR-106) is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.
TP1886L1 NoxA1ds acetate(1435893-78-9 free base) NADPH-oxidase
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col...
T3437 Lys05 Lys01 trihydrochloride lysosomal autophagy , Autophagy
Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compa...
T2511 Plinabulin NPI-2358 Microtubule Associated
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the...
T2283 PX-12 IV-2,PX12 Thioredoxin
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr...
T17010 TC13172 Others
TC13172 is an inhibitor of mixed lineage kinase domain-like protein (EC50: 2 nM for HT-29 cells).
T36321 C6 Urea Ceramide
C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It i...
T63590 C-Met-IN-10
c-Met-IN-10 is a potent c-Met kinase inhibitor (IC50: 16 nM). c-Met-IN-10 inhibits the activity of cancer cells A549, H460 and HT-29, and inhibits A549 cell movement by inhibiting HT-29 cell colony formation, which in tu...
T16034 Meclinertant SR 48692 Others
Meclinertant is an effective, selective, nonpeptide, and orally active neurotensin receptor 1 (NTS1) antagonist. Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization (pA2 : 8.13), in...
T32372 Keenamide A
Keenamide A, a cytotoxic cyclic hexapeptide, exhibits significant activity towards the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive against the D6 and W2 Plasmodium falciparum malarial clones.
T82802 BX-2819 HSP
BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM . It effectively suppresses the growth of NCI-N87 and HT-29 tumor cells in nude mice[1].
T72544 4-Formylcolchicine
4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC 50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively .
T62642 Microtubule inhibitor 4
Microtubule inhibitor 4 (compound 2) is a potent inhibitor of microtubule and inhibits microtubule protein polymerization, HT-29 cells (IC50: 2.1 nM) exhibited cytotoxicity.
T73677 SR 142948 dihydrochloride
SR 142948 dihydrochloride is an orally active and selective non-peptide neurotensin receptor ( NT ) antagonist with IC 50 s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively...
T69589 PX-316
PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor act...
T40903 ACG416B
ACG416B (compound 18) exhibits formidable inhibitory effects on choline kinase (ChoK), with an IC 50 measurement of 0.4 μM. Notably, ACG416B demonstrates superior inhibitory activities against HT-29 human colon cancer ce...
T79715 C-Met-IN-19 c-Met/HGFR
c-Met-IN-19 (Compound 21j) is a potent c-Met inhibitor with an IC50 of 1.99 nM and demonstrates cytotoxic effects on various cancer cell lines, including A549, HT-29, SGC-7901, and MDA-MB-231, with IC50 values of 0.25, 0...
T83008 Antitumor agent-119
Antitumor agent-119 (compound 13K), a 2-benzoxazolyl hydrazone derivative, exhibits anticancer capabilities by impeding the proliferation of Burkitt, CCRF-CEM, HeLa, and HT-29 cells, with respective IC50 values of 30 nM,...
T78959 ATR-IN-23 ATM/ATR
ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility ...
T62503 EGFR/BRAFV600E-IN-1
EGFR/BRAFV600E-IN-1 (Compound 23) is a potent dual inhibitor of EGFR (IC50: 0.08 μM) and BRAFV600E (IC50: 0.15 μM). EGFR/BRAFV600E-IN-1 exhibited anti-proliferative effects on A-549 (IC50: 1.2 μM), MCF-7 (IC50: 0.79 μM),...
T36398 Paclitaxel octadecanedioate
Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a ...
T79401 Tyrosinase-IN-13 Tyrosinase
Tyrosinase-IN-13 (compound 3c), stemming from Flurbiprofen, acts as a potent non-competitive inhibitor of tyrosinase, exhibiting IC50 and Ki values of 68 μM and 36.3 μM respectively. This compound demonstrates cytotoxici...
T75949 NoxA1ds TFA
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC 50 =20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2 , NOX4 , NOX5 and xanthine oxidase . NoxA1ds TFA inhibits NOX1-derived O2- produc...
T62448 Microtubule inhibitor 6
Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. microtubule inhibitor 6 exhibited cytotoxicity against NCI-H460 cells, BxPC-3 cells, and HT-29 cells, with IC50 values of 14.0, 6.6, and 7.0 nM, r...
T79143 MS934 MEK
MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM. It holds potential for researching various human cancers including melanoma, ...
T36867 4-(Dimethylamino)-1-methylpyridinium (iodide)
4-(Dimethylamino)-1-methylpyridinium is a monoquaternary pyridinium salt with anticholinesterase and antiproliferative activities. It inhibits cholinesterase activity in rat brain homogenates with a Kd value of 33 μM and...
TP1886 NoxA1ds
Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Atte...
T71055 Albendazole-d7
Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helmi...
T78844 MET/PDGFRA-IN-2 c-Met/HGFR
MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positive cells with IC50 values of 9.7, 6.1, 12.0, 11.5, 8.6, and 34.4 μ...
T36477 Urdamycin A
Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilis...
T78843 MET/PDGFRA-IN-1 c-Met/HGFR
MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET. It impedes MET phosphorylation, thereby promoting apoptosis, and curtails the proliferation of var...
T36318 28-Acetylbetulin
28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inM. chiapensisand has anti-inflammatory and anticancer activities.1,2It inhibits LPS-induced...
T83736 RTDLDSLRTYTL TFA
RTDLDSLRTYTL is a ligand for αVβ6 integrin, exhibiting selective inhibition of fibronectin's binding to αVβ6 integrin with considerably less effect on the interactions between vitronectin and αVβ3 or αVβ5, as well as fib...
T81446 PKM2 activator 6
Compound Z10 (PKM2 activator 6) serves as both a PKM2 activator and a PDK1 inhibitor, exhibiting dissociation constants (K D ) of 121 μM and 19.6 μM, respectively. It promotes apoptosis in colorectal cells while suppress...
T36035 CAY10784
CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 ...
T35438 (5E)-7-Oxozeaenol
(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxoz...
T36452 1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is...
T71303 Flufenamic Acid-d4
Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and...
T81272 RIOK2-IN-1
RIOK2-IN-1 (com 4) is a selective RIOK2 inhibitor with a Kd of 150 nM, though it demonstrates low cellular activity with an IC50 of 14,600 nM. As an atypical kinase, RIOK2's involvement in ribosome maturation and cell cy...
T36314 Wortmannin-Rapamycin Conjugate
Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin...
T36096 Thiocoraline
Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. lut...

Compounds

CAN508
T8796
Synonym:
Target: CDK
β-catenin-IN-2
T9696
Synonym:
Target: Wnt/beta-catenin
PROTAC BRAF-V600E degrader-1
T8745
Synonym: Compound 23
Target: Raf
Apostatin-1
T9079
Synonym: Apt-1
Target: Others
Sertindole
T5858
Synonym: Lu 23-174
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy
Prexasertib dihydrochloride
T4327
Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368
Target: Apoptosis, Chk, S6 Kinase
Prexasertib
T4310
Synonym: LY2606368
Target: Apoptosis, Chk
SR 142948
T23386
Synonym:
Target: Neurotensin Receptor
IL-17A inhibitor 1
T9448
Synonym:
Target: IL Receptor
ZYN57939
T9051
Synonym: MTR-106
Target: DNA/RNA Synthesis
NoxA1ds acetate(1435893-78-9 free base)
TP1886L1
Synonym:
Target: NADPH-oxidase
Lys05
T3437
Synonym: Lys01 trihydrochloride
Target: lysosomal autophagy, Autophagy
Plinabulin
T2511
Synonym: NPI-2358
Target: Microtubule Associated
PX-12
T2283
Synonym: IV-2,PX12
Target: Thioredoxin
TC13172
T17010
Synonym:
Target: Others
C6 Urea Ceramide
T36321
Synonym:
Target:
c-Met-IN-10
T63590
Synonym:
Target:
Meclinertant
T16034
Synonym: SR 48692
Target: Others
Keenamide A
T32372
Synonym:
Target:
BX-2819
T82802
Synonym:
Target: HSP
4-Formylcolchicine
T72544
Synonym:
Target:
Microtubule inhibitor 4
T62642
Synonym:
Target:
SR 142948 dihydrochloride
T73677
Synonym:
Target:
PX-316
T69589
Synonym:
Target:
ACG416B
T40903
Synonym:
Target:
c-Met-IN-19
T79715
Synonym:
Target: c-Met/HGFR
Antitumor agent-119
T83008
Synonym:
Target:
ATR-IN-23
T78959
Synonym:
Target: ATM/ATR
EGFR/BRAFV600E-IN-1
T62503
Synonym:
Target:
Paclitaxel octadecanedioate
T36398
Synonym:
Target:
Tyrosinase-IN-13
T79401
Synonym:
Target: Tyrosinase
NoxA1ds TFA
T75949
Synonym:
Target:
Microtubule inhibitor 6
T62448
Synonym:
Target:
MS934
T79143
Synonym:
Target: MEK
4-(Dimethylamino)-1-methylpyridinium (iodide)
T36867
Synonym:
Target:
NoxA1ds
TP1886
Synonym:
Target:
Albendazole-d7
T71055
Synonym:
Target:
MET/PDGFRA-IN-2
T78844
Synonym:
Target: c-Met/HGFR
Urdamycin A
T36477
Synonym:
Target:
MET/PDGFRA-IN-1
T78843
Synonym:
Target: c-Met/HGFR
28-Acetylbetulin
T36318
Synonym:
Target:
RTDLDSLRTYTL TFA
T83736
Synonym:
Target:
PKM2 activator 6
T81446
Synonym:
Target:
CAY10784
T36035
Synonym:
Target:
(5E)-7-Oxozeaenol
T35438
Synonym:
Target:
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
T36452
Synonym:
Target:
Flufenamic Acid-d4
T71303
Synonym:
Target:
RIOK2-IN-1
T81272
Synonym:
Target:
Wortmannin-Rapamycin Conjugate
T36314
Synonym:
Target:
Thiocoraline
T36096
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TQ0265 Indolelactic acid Endogenous Metabolite
Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.
T35673 Stictic Acid Scopularic acid Others
Stictic Acid (Scopularic acid) is isolated from a Sumatran lichen Stereocaulon montagneanum and inhibits the growth of HT-29 human colon adenocarcinoma cells with an IC50 of 29.29 μg/ml.
T37067 9-hydroxy Stearic Acid HDAC
9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (...
TN2083 Pinostrobin chalcone
Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 c...
TN1727 Helichrysetin Apoptosis , HIV Protease
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.
T5S1607 Morusin Mulberrochromene NF-κB , Antibacterial , STAT
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti...
T2S2382 3'-Hydroxypterostilbene 3'-HPT Apoptosis , Autophagy
3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, b...
TN1405 Arnicolide D Akt , Caspase , PI3K , STAT , mTOR
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...
TN1776 Isocucurbitacin B Others
Isocucurbitacin B has significant activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73uM.
TN3445 Aristolactam BIII PAFR
Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro.
TN1173 1-Hydroxyrutaecarpine Others
1-Hydroxyrutaecarpine exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.
TN1993 Norsanguinarine Antifection
Norsanguinarine has antifungal activity, it exhibits 100 % inhibition of A. brassicicola and C. maculans at 1000 ppm whereas. It shows significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, ...
TN2695 2,3-Dihydroamentoflavone 7,4'-dimethyl ether Others
2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.
T81856 Marsdenoside B
Marsdenoside B (compound 8), an isolate from the Alocasia genus, exhibits antitumor activity by inhibiting the proliferation of MGC-803 and HT-29 tumor cell lines with IC50 values of 25.6 μg/mL and 32.4 μg/mL, respective...
T81857 Marsdenoside A
Marsdenoside A (compound 7), an isolated compound from the Alocasia genus, exhibits a weak inhibitory effect on the growth of two tumor cell lines, MGC-803 and HT-29, with IC50 values exceeding 50 μg/mL.
TN4146 Glutinol acetate TNF
Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits mo...
TN1349 9-Hydroxycalabaxanthone Antifection
9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α±-mangostin shows the synergistic antimalarial interaction in bot...
TMA0291 Dehydroglyasperin D GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit...
T5S0506 Rotundic acid Rutundic acid Apoptosis , Others , p38 MAPK , Akt , mTOR
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...
TN3870 Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol Others
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against t...
TargetMol