gemcitabine — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0251	Gemcitabine	NSC 613327,LY188011	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Autophagy
	Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
T6069	Gemcitabine hydrochloride	Gemcitabine HCl,Gemzar,LY188011,LY 188011 hydrochloride	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Autophagy
	Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy a...
T15378L	Gemcitabine elaidate hydrochloride	CO-101 hydrochloride,Gemcitabine elaidate hydrochloride(210829-30-4(free base)),Gemcitabine 5'-elaidate hydrochloride,CP-4126 hydrochloride	Others
	Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. In contrast to gemcitabine, G...		Others
T15378	Gemcitabine elaidate	Gemcitabine 5'-elaidate,Gemcitabine (elaidate),CO-101,CP-4126	Apoptosis , Nucleoside Antimetabolite/Analog , Autophagy
	Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracel...		Apoptosis , Nucleoside Antimetabolite/Analog , Autophagy
T21329	Gemcitabine monophosphate disodium salt	Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP
	R306465 is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro.
T4187	Gemcitabine monophosphate sodium salt hydrate		Others , DNA , DNA/RNA Synthesis , Autophagy
	Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.		Others , DNA , DNA/RNA Synthesis , Autophagy
T75252	Gemcitabine triphosphate
	Gemcitabine triphosphate (dFdCTP), alongside its counterpart, the active diphosphate (dFdCDP), represents one of the two primary nucleoside metabolites of Gemcitabine within cellular structures. It serves as a benchmark ...
T17985	Gemcitabine-O-Si(di-iso)-O-Mc		Others
	Gemcitabine-O-Si(di-iso)-O-Mc, a drug-linker conjugate for Antibody-Drug Conjugates (ADC), exhibits potent antitumor activity. It incorporates Gemcitabine, a pyrimidine nucleoside analog antimetabolite and antineoplastic...		Others
T4061	LY2334737		Nucleoside Antimetabolite/Analog , Others , Virus Protease
	LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.		Nucleoside Antimetabolite/Analog , Others , Virus Protease
T6028	PF 477736	PF 00477736,PF-477736,PF-736,PF-00477736,PF477736	c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T4060	Acelarin	NUC-1031	DNA/RNA Synthesis
	Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.		DNA/RNA Synthesis
T67291	2′,2′-Difluorodeoxyuridine	dFdU,2',2'-Difluoro-2'-deoxyuridine	Drug Metabolite
	2′,2′-Difluorodeoxyuridine (dFdU) is the major metabolite of Gemcitabine.2′,2′-Difluorodeoxyuridine has anticancer and antitumor activity, and shows radiosensitization under hypoxic conditions, and can be used to study p...		Drug Metabolite
T41345	AFMK	Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine	Apoptosis , Free radical scavengers , Antioxidant , Endogenous Metabolite
	AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine ...
T16813	RX-3117	fluorocyclopentenylcytosine,TV-1360	Nucleoside Antimetabolite/Analog
	RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog. RX-3117 displays anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.		Nucleoside Antimetabolite/Analog
T4126	CBL0137	Curaxin 137,CBLC137	NF-κB , p53
	CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the eff...		NF-κB , p53
T71259	GNE-900	GNE900,GNE 900	Apoptosis , Chk
	GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 ...		Apoptosis , Chk
T19779	SL-01	Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone
	SL-01 is an oral derivative of gemcitabine. SL-01 inhibited human breast cancer growth through the induction of apoptosis. SL-01 inhibited human cancer growth more potently than gemcitabine.
T79198	S-Gem		Nucleoside Antimetabolite/Analog
	S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR. Studies indicate that S-Gem exhibits lower cytotoxicity than Gemcitabine [1].		Nucleoside Antimetabolite/Analog
T17175	Troxacitabine	BCH-4556,SGX-145,SGX145,SPD-758,BCH4556,beta-L-OddC	Others
	Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious ...		Others
T18313	Mc-O-Si(di-iso)-Cl		Others
	Mc-O-Si(di-iso)-Cl is a cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs) like Gemcitabine-O-Si(di-iso)-O-Mc [1].		Others
T39290	FF-10502
	FF-10502 is a pyrimidine nucleoside antimetabolite and a structural analog of Gemcitabine. This compound effectively inhibits DNA polymerase α and β, demonstrating potent anticancer activity by targeting dormant cells.
T82327	GEM–IB
	Gemcitabine-ibandronate (GEM–IB), a conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB), exhibits efficacy both as a monotherapy and synergistically with Docetaxel (DTX), resulting in diminished tumor burde...
T68981	PD-321852
	PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibi...
T74400	TC113
	TC113, a Gemcitabine (GEM)-based conjugate incorporating the c(RGDyK) sequence, is internalized by A549 cells via the integrin αvβ3 pathway. It demonstrates significant antiproliferative effects on both WM266.4 and A549 ...
T18369	N-(5-Hydroxypentyl)maleimide		Others
	N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a crucial component in the production of Gemcitabine-O-Si(di-iso)-O-Mc, an A...		Others
T63074	Ivaltinostat formic
	Ivaltinostat (CG-200745) formic is an oral active panHDAC inhibitor with an isohydroxamic acid component that binds zinc at the bottom of the catalytic pocket. Ivaltinostat formic inhibited the deacetylation of histone H...
T74765	Viral polymerase-IN-1 hydrochloride
	Viral polymerase-IN-1 hydrochloride, a derivative of Gemcitabine, effectively inhibits influenza A and B virus infections, demonstrating IC90 values ranging from 11.4 to 15.9 μM, and possesses activity against SARS-CoV-2...
T79689	SIRT6-IN-3		Sirtuin
	SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to ...		Sirtuin
T74530	GEM-5
	GEM-5, a gemcitabine-based conjugate incorporating a HIF-1α inhibitor (YC-1) (IC 50 =30 nM), notably suppresses HIF-1α expression while enhancing tumor suppressor p53 expression. It induces apoptosis in A2780 cells and c...
T17059	Tetrahydrouridine	NSC 112907,NSC112907,NSC-112907	DNA Methyltransferase
	Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator. It can be used in cancer treatment to make tumor cells more sensitive to radiation therapy. THU is a competitive cytidine deaminase(CDA) inhibitor ...		DNA Methyltransferase
T36103	TW9	TW9
	TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μ...
T70928	CB-1158-analog
	CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vi...
T36424	DSPE-PEG(2000)-amine (sodium salt)
	DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3D...

Compounds

Gemcitabine

T0251

Synonym: NSC 613327,LY188011

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Gemcitabine hydrochloride

T6069

Synonym: Gemcitabine HCl,Gemzar,LY188011,LY 188011 hydrochloride

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Gemcitabine elaidate hydrochloride

T15378L

Synonym: CO-101 hydrochloride,Gemcitabine elaidate hydrochloride(210829-30-4(free base)),Gemcitabine 5'-elaidate hydrochloride,CP-4126 hydrochloride

Target: Others

Gemcitabine elaidate

T15378

Synonym: Gemcitabine 5'-elaidate,Gemcitabine (elaidate),CO-101,CP-4126

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Autophagy

Gemcitabine monophosphate disodium salt

T21329

Synonym: Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP

Target:

Gemcitabine monophosphate sodium salt hydrate

T4187

Synonym:

Target: Others, DNA, DNA/RNA Synthesis, Autophagy

Gemcitabine triphosphate

T75252

Synonym:

Target:

Gemcitabine-O-Si(di-iso)-O-Mc

Target: Nucleoside Antimetabolite/Analog, Others, Virus Protease

PF 477736

T6028

Synonym: PF 00477736,PF-477736,PF-736,PF-00477736,PF477736

Target: c-Fms, VEGFR, FGFR, FLT, c-RET, Chk, CDK, Src, Aurora Kinase

Acelarin

T4060

Synonym: NUC-1031

Target: DNA/RNA Synthesis

2′,2′-Difluorodeoxyuridine

T67291

Synonym: dFdU,2',2'-Difluoro-2'-deoxyuridine

Target: Drug Metabolite

AFMK

T41345

Synonym: Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine

Target: Apoptosis, Free radical scavengers, Antioxidant, Endogenous Metabolite

RX-3117

T16813

Synonym: fluorocyclopentenylcytosine,TV-1360

Target: Nucleoside Antimetabolite/Analog

CBL0137

T4126

Synonym: Curaxin 137,CBLC137

Target: NF-κB, p53

GNE-900

T71259

Synonym: GNE900,GNE 900

Target: Apoptosis, Chk

SL-01

T19779

Synonym: Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone

Target: Nucleoside Antimetabolite/Analog

Troxacitabine

T17175

Synonym: BCH-4556,SGX-145,SGX145,SPD-758,BCH4556,beta-L-OddC

N-(5-Hydroxypentyl)maleimide

Viral polymerase-IN-1 hydrochloride

Synonym: NSC 112907,NSC112907,NSC-112907

Target: DNA Methyltransferase

DSPE-PEG(2000)-amine (sodium salt)

T36424

Synonym:

Target:

Cat No.	Product Name	Species	Expression System
TMPY-03329	DPEP1 Protein, Human, Recombinant (His)	Human	HEK293
	Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correl...

Cat No.	Product Name
L5100	Fluorochemical Library		583 compounds
	A unique collection of 583 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);

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