Search Result

Search Results for " gpx "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T67970	GPX-100	13-deoxydoxorubicin	Others
	GPX-100 (13-deoxydoxorubicin) is an analogue of the anthracycline antitumour antibiotic doxorubicin. GPX-100 inserts into DNA and interacts with topoisomerase II to inhibit DNA replication and repair as well as RNA and p...		Others
T68928	GPX100 HCl
	GPX-100 is a n analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesi...
T69668	CCW 28-3
	CCW 28-3 is a novel potent covalent BRD4 degrader, degrading BRD4 in a proteasome- and RNF4-dependent manner without inhibiting RNF4 autoubiquitination activity.
T77755	GPX4-IN-5		GPX
	GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces iron death and can be used for the prevention and treatment of triple-negative breast cancer (TNBC).		GPX
T77759	GPX4-IN-6		GPX
	GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces iron death and is used for the treatment= and prevention of triple negative breast cancer (TNBC).		GPX
T83780	GPX4 24	Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24
	GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound e...
T74846	GPX4-IN-4		Glutathione Peroxidase
	GPX4-IN-4 (Compound 24) serves as a potent inhibitor of GPX4, applicable in cancer research [1].		Glutathione Peroxidase
T63729	GPX4-IN-3
	GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis. It demonstrates a 71.7% inhibition rate of GPX4 at a concentration of 1 μM [1].
T74796	PROTAC GPX4 degrader-1
	PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080 cells [1].
T73235	GPX4-IN-2
	GPX4-IN-2 is a potent inhibitor of GPX4, exhibiting antiproliferative activity. It holds potential for cancer research applications.
T79777	GPX4-IN-7		Ferroptosis
	GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment. Exhibiting potent antitumor properties, it inhibits HCT-116 cell growth with an IC50 of 0.49 μM. This compound ...		Ferroptosis
T21899	Misonidazole	SR-1354,SR1354,Ro 7-0582	GPX
	Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.		GPX
T69669	Camsirubicin HCl
	Camsirubicin, also known as GPX-150, MNPR-201, and CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 inte...
T11357	Gamma-glutamylcysteine TFA	γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)	IL Receptor
	Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), a crucial dipeptide in glutathione (GSH) synthesis and a vital cofactor for the enzyme glutathione peroxidase (GPx), significantly modulates inflammatory response...		IL Receptor
T36516	RC574	RC574
	RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons...
T63768	Antitumor agent-78
	Antitumor agent-78 inhibits GPx-4 and elevates COX2, leading to ferroptosis. antitumor agent-78 activates the tumor cell intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and inhibits the epithelial mesenchymal transitio...
T62814	Antitumor agent-77
	Antitumor agent-77 inhibits the growth and migration of cancer cells and has anticancer effects. antitumor agent-77 inhibits GPx-4 and enhances COX2-induced iron sagging. antitumor agent-77 activates the intrinsic apopto...
T36515	RC363
	RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a...

Compounds

GPX-100

T67970

Synonym: 13-deoxydoxorubicin

Synonym: Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24

Target: Glutathione Peroxidase

PROTAC GPX4 degrader-1

Synonym: SR-1354,SR1354,Ro 7-0582

Gamma-glutamylcysteine TFA

T11357

Synonym: γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-06701	GPX4 Protein, Human, Recombinant (His)	Human	E. coli
	GPX4 Protein, Human, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 20.59 kDa. Accession number: P36969
TMPY-02843	GPX7 Protein, Human, Recombinant (hFc)	Human	HEK293
	GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to ...
TMPH-03108	GPX5 Protein, Pig, Recombinant (E. coli, His & Myc)	Sus scrofa (Pig)	E. coli
	May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxi...
TMPH-02681	GPX7 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
TMPH-01296	GPX5 Protein, Human, Recombinant (GST & His)	Human	E. coli
	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective syste...
TMPH-03109	GPX5 Protein, Pig, Recombinant (His & Myc)	Sus scrofa (Pig)	Yeast
	May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxi...
TMPH-03443	GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)	Saccharomyces cerevisiae	E. coli
	Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the pres...
TMPY-02201	Peroxiredoxin 6 Protein, Human, Recombinant (His)	Human	E. coli
	PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is...