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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13017 | STL127705 | Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione | DNA-PK , Others |
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activation of Ku-dependent DNA-PKCS kinase with IC50 of 2.5 μM. | |||
T2693 | AG1024 | Tyrphostin AG 1024,Tyrphostin,AGS 200 | Apoptosis , IGF-1R |
AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM). | |||
T61857 | DNA-PK-IN-4 | ||
DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly imp... | |||
T61633 | DNA-PK-IN-2 | ||
DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a complex enzyme composed of Ku70/Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). With its potential applications i... | |||
T62191 | DNA-PK-IN-5 | ||
DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits the activity of DNA-PKcs, significantly reduces tumour DNA repair and induces apoptosis. DNA-PK-IN-5 improves the sensitivity of tumour tissue to radiothe... | |||
T61370 | DNA-PK-IN-6 | ||
DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 ampli... | |||
T64204 | NU5455 | ||
NU5455 is a selective, potent, orally active inhibitor of DNA-PKcs. NU5455 enhances the efficacy of locally released doxorubicin in liver tumour xenografts without causing any adverse effects. nU5455 enhances the efficac... | |||
T62648 | DNA-PK-IN-1 | ||
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research. |