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Results for "

DNA-PK

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    78
    TargetMol | Activity
  • Recombinant Protein
    5
    TargetMol | inventory
  • Isotope Products
    2
    TargetMol | natural
DNA-PK-IN-10
T791652919315-89-0
DNA-PK-IN-10 is a DNA-PK inhibitor used in breast cancer and non-small cell lung cancer research [1].
  • Inquiry Price
8-10 weeks
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NU 7026
T2433154447-35-5
NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
  • $33
In Stock
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TargetMol | Inhibitor Sale
LY294002
T2008154447-36-6
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
  • $27.2
  • $34
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
PIK-75
T2667372196-67-3
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
  • $38
In Stock
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TargetMol | Citations Cited
IC 86621
T9760404009-40-1
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cellular DSB repair.
  • $32
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TargetMol | Inhibitor Sale
STL127705
T130171326852-06-5In house
STL127705 (Compound L) is a potent inhibitor of the Ku 70 80 heterodimer protein, disrupting Ku70 80-DNA interaction with an IC50 of 3.5 μM, and inhibiting Ku-dependent DNA-PKCS kinase activation with an IC50 of 2.5 μM.
  • $116
In Stock
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Wortmannin
T628319545-26-7
Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8 48 nM) that blocks autophagy.
  • $32
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TargetMol | Citations Cited
OSI-027
T6319936890-98-1
OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1.
  • $35
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
KU-57788
T6276503468-95-9
NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).
  • $34
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Torin 2
T61001223001-51-1
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 28 nM/35 nM/118 nM, respectively.
  • $35
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
KU-55933
T2685587871-26-9
KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor (IC50=12.9 nM; Ki=2.2 nM) that is selective and ATP-competitive. KU-55933 induces apoptosis and has antitumor effects.
  • $43
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Torin 1
T60451222998-36-8
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
  • $30
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TargetMol | Citations Cited
NU6027
T6612220036-08-8
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
  • $38
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TargetMol | Inhibitor Sale
CC-115
T35411228013-15-7
CC-115 is a inhibitor of mTOR DNA-PK (IC50= 21 13 nM).
  • $38
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TargetMol | Inhibitor Sale
KU-0060648
T6557881375-00-4
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 values of 8.6 nM, 4 nM, 0.5 nM, and 0.1 nM respectively, and demonstrates less inhibition of PI3Kγ with an IC50 of 0.59 μM.
  • $54
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TargetMol | Inhibitor Sale
Voxtalisib
T7014934493-76-2
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1 2.
  • $43
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TargetMol | Inhibitor Sale
Samotolisib
T68831386874-06-1
Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, BREAST CANCER, and Advanced Cancer, among others.
  • $30
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TargetMol | Inhibitor Sale
Pictilisib dimethanesulfonate
T11381957054-33-0
Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
  • $32
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TargetMol | Inhibitor Sale
DMNB
T863720357-25-9
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells.
  • $29
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TargetMol | Inhibitor Sale
YU238259
T43391943733-16-1
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
  • $34
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TargetMol | Inhibitor Sale
BAY-8400
T9498
BAY-8400 is a potent, selective, and orally active DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 = 81 nM) that demonstrates synergistic efficacy when combined with targeted alpha therapies. BAY-8400 is applicable for cancer research [1].
  • $77
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TargetMol | Inhibitor Sale
Compound 401
T3586168425-64-7
Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
  • $29
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TargetMol | Inhibitor Sale
ETP-45658
T253991198357-79-7
ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively).
  • $29
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TargetMol | Inhibitor Sale
SF2523
T39861174428-47-7
SF2523 is a highly selective and potent inhibitor (SF2523) with improved physicochemical properties, excellent aqueous solubility, and biological efficacy. It is typically used in genome editing [CRISPR Cas Solution] technology and can effectively enhance the efficiency of this process.
  • $31
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TargetMol | Inhibitor Sale
LTURM34
T157891879887-96-3
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .
  • $38
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TargetMol | Inhibitor Sale
ETP-46464
T20841345675-02-6
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
  • $34
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TargetMol | Inhibitor Sale
Pilaralisib analogue
T2377956958-53-5
Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor targeting PI3Kα δ γ.
  • $29
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TargetMol | Inhibitor Sale
PIK-93
T2616593960-11-3
PIK-93, the first potent synthetic PI4K inhibitor, exhibits an IC50 of 19 nM and also inhibits PI3Kα with an IC50 of 39 nM.
  • $29
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TargetMol | Inhibitor Sale
PI-3065
T2083955977-50-1
PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
  • $44
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TargetMol | Inhibitor Sale
PIK-90
T2461677338-12-4
PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
  • $39
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ZL-2201
T786452865115-39-3
ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.
  • Inquiry Price
8-10 weeks
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PI3K-IN-1
T18261349796-36-6
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
  • $30
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PI-103
T6143371935-74-9
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
  • $52
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TargetMol | Inhibitor Sale
AZD-7648
T71222230820-11-6
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
  • $34
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PIK-75 hydrochloride
T2287372196-77-5
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.
  • $36
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Leniolisib
T51661354690-24-6
Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
  • $72
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VX-984
T110671476074-39-1
VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies.
  • $177
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AZD 6482
T60871173900-33-8
AZD 6482 (AZD6482) is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
  • $31
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TargetMol | Inhibitor Sale
(R)-(-)-Rolipram
T1344885416-75-7
(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
  • $39
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Onatasertib
T33511228013-30-6
Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Onatasertib is a potent mTOR kinase inhibitor (IC50: 16 nM), with >150-fold sensitivity than the related lipid kinase PI3Kα (IC50: 4 μM).
  • $35
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DNA-PK-IN-3
T617512734846-19-4
DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK that exerts a synergistic effect with radiotherapy and chemotherapy, enhancing therapeutic outcomes and significantly inhibiting tumor growth. Additionally, it demonstrates remarkable efficacy in reducing damage to normal cells, thereby minimizing adverse side effects, making it a compound of great potential for cancer research applications[1].
  • $2,140
6-8 weeks
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DNA-PK-IN-1
T626482663850-40-4
DNA-PK-IN-1, a potent inhibitor of DNA-PK, holds potential for cancer disease research.
  • $2,140
6-8 weeks
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DNA-PK-IN-2
T616332665720-22-7
DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme complex comprising the Ku70 Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). It shows potential applications in cancer research, making it a valuable tool for studying cancer diseases [1].
  • $1,520
10-14 weeks
Size
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DNA-PK-IN-12
T862892792146-91-7
DNA-PK-IN-12 (compound 31t), an orally active inhibitor of DNA-PK, demonstrates potent inhibition with an IC 50 of 0.1 nM. It effectively impedes Hct116 cell growth and colony formation, displaying an IC 50 of 33.28 μM, and exhibits antitumor activity in vivo [1].
  • Inquiry Price
10-14 weeks
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QTY
DNA-PK-IN-8
T618282823369-81-7
DNA-PK-IN-8 is a potent, selective, and orally active inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 0.8 nM, demonstrating synergistic antiproliferative effects across various cancer cell lines and significantly reducing HL-60 tumor growth when combined with Doxorubicin [1].
  • $1,520
10-14 weeks
Size
QTY
DNA-PK-IN-9
T61533
DNA-PK-IN-9 (also known as compound YK6) is a highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), displaying an IC50 value of 10.47 nM. DNA-PK-IN-9 holds significant potential in anticancer research [1].
  • $1,520
10-14 weeks
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DNA-PK-IN-6
T613702711810-41-0
DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 amplifies the responsiveness of tumor tissues to radiotherapy, overcomes the challenge of drug resistance, and augments its inhibitory impact on a diverse range of solid and hematological tumors[1].
  • $2,140
10-14 weeks
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DNA-PK-IN-4
T618572722645-10-3
DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly impairs tumor DNA repair mechanisms and triggers apoptosis in cells. With its potential application in cancer research, DNA-PK-IN-4 holds promise for further investigation [1].
  • $1,520
6-8 weeks
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