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637-32-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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  • Isotope Products
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    TargetMol | inventory
Proguanil hydrochloride
T4382637-32-1
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
  • $50
In Stock
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QTY
Proguanil
T22409500-92-5
Proguanil, a prophylactic antimalarial drug, inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of pyrimidines and purines, which are essential for DNA synthesis and cell multiplication.
  • $120
35 days
Size
QTY
Proguanil D6
T12545
Proguanil D6 is the deuterium labeled Proguanil, and is an agent of prophylactic antimalarial.
  • $188
Backorder
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Proguanil-d6 HCl
TMIH-0457
Proguanil-d6 HCl is a deuterated compound of Proguanil HCl. Proguanil HCl has a CAS number of 637-32-1. Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
  • $653
7-10 days
Size
QTY