6-oh-bta-0

6-OH-BTA-0 (11C-PiB Precursor) is an intermediate for synthetic pesticides and a precursor of 6-OH-BTA-1, which can be used to synthesize β-amyloid imaging agents.

D-Fructose-6-phosphate (sodium salt hydrate) is a sugar intermediate in the glycolytic pathway produced by the isomerization of glucose 6-phosphate by glucose phosphate isomerase, and is used in cancer research.

Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300 CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostaglandin synthase, lipoxygenase, and tyrosinase.

1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid is a useful organic compound for research related to life sciences. The catalog number is Fr21307 and the CAS number is 5382-49-0.

6-O-(2-Methylbutyryl)helenalin is a useful organic compound for research related to life sciences. The catalog number is T123878 and the CAS number is 94729-11-0.

4'-O-(6-O-Feruloylglucopyranosyl)phloretin is a useful organic compound for research related to life sciences. The catalog number is T125389 and the CAS number is 2058292-99-0.

6-Keto Cholestanol is a useful organic compound for research related to life sciences. The catalog number is T126283 and the CAS number is 1175-06-0.

06:0 PE (PE(6:0 6:0)) is a water-soluble phospholipid characterized by its short acyl chains. It possesses notable antitumor activity and can inhibit tumor progression in the body. Additionally, it exhibits antiproliferative and pro-apoptotic properties, and serves as a precursor for phosphatidylcholine and phosphatidylethanolamine.

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine (18:0-22:6 PE) is a lipid compound utilized in the preparation of liposomes. Liposomes, forming the central component of concentric phospholipid bilayer vesicles, are pivotal in constructing drug delivery systems for anti-cancer and anti-infection applications. They effectively encapsulate hydrophilic payloads within their aqueous internal spaces, while lipophilic compounds are integrated into and become part of the lipid bilayer. This compound is particularly effective for delivering antisense oligonucleotides, addressing challenges such as inefficient cellular uptake and rapid loss in the body.

1,3-Didocosahexaenoyl glycerol (DG(22:6 0:0 22:6)) is an ω-3 polyunsaturated fatty acid that exhibits cardioprotective effects in a rat myocardial ischemia reperfusion (I R) injury model through its interaction with Poly-l-glutamic acid (PGA).

C14 Ceramide (d18:1 14:0) is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson's research.

C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM).

C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells in vitro (IC50 = 18 μM), metabolically inactive, and unlike C6 L-erythro ceramide, it cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 L-threo Ceramide enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells at 10 μM.

C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM.

Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation. Ganglioside GM1acts as a receptor for cholera toxin, which binds to its oligosaccharide group, facilitating toxin cell entry into epithelial cells of the jejunum.4,5Similarly, it is bound by the heat-labile enterotoxin fromE. coliin the pathogenesis of traveler's diarrhea.6Ganglioside GM1gangliosidosis, characterized by a deficiency in GM1-β-galactosidase, the enzyme that degrades ganglioside GM1, leads to accumulation of the gangliosides GM1and GA1in neurons and can be fatal in infants.1Levels of ganglioside GM1are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson's disease.3Ganglioside GM1mixture contains a mixture of ovine ganglioside GM1molecular species with primarily C18:0 fatty acyl chain lengths, among various others. [Matreya, LLC. Catalog No. 1544] 1.Kolter, T.Ganglioside biochemistryISRN Biochem.506160(2012) 2.Mocchetti, I.Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophinsCell Mol. Life Sci.62(19-20)2283-2294(2005) 3.Ledeen, R.W., and Wu, G.The multi-tasked life of GM1 ganglioside, a true factotum of natureTrends Biochem. Sci.40(7)407-418(2015) 4.Turnbull, W.B., Precious, B.L., and Homans, S.W.Dissecting the cholera toxin-ganglioside GM1 interaction by isothermal titration calorimetryJ. Am. Chem. Soc.126(4)1047-1054(2004) 5.Blank, N., Schiller, M., Krienke, S., et al.Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1Immunol. Cell Biol.85(5)378-382(2007) 6.Minke, W.E., Roach, C., Hol, W.G., et al.Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonistsBiochemistry38(18)5684-5692(1999)

TBK1 IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced activity, by 100- to 1000-fold, against other protein kinases, such as PDK1, PI3K family members, and mTOR[1].

Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).

2-Ethyl-6-methoxynaphthalene is a useful organic compound for research related to life sciences. The catalog number is T64478 and the CAS number is 21388-17-0.

6-Methoxynaphthalen-2-ol is a useful organic compound for research related to life sciences. The catalog number is T65163 and the CAS number is 5111-66-0.

(2R,3R,4S,5R)-2-(6-(Benzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is a natural product for research related to life sciences. The catalog number is T65346 and the CAS number is 4294-16-0.

N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T66148 and the CAS number is 289042-10-0.

2,3-Dimethyl-2H-indazol-6-amine is a useful organic compound for research related to life sciences. The catalog number is T66273 and the CAS number is 444731-72-0.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66316 and the CAS number is 159857-60-0.

(2S,5R,6S)-Benzhydryl 6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide is a useful organic compound for research related to life sciences. The catalog number is T66344 and the CAS number is 80353-26-0.