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By Target- Antibacterial
- Cytochromes P450(1)
- PDE(1)
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Results for "
4,5-dimethoxycanthin-6-one
" in TargetMol Product Catalog- Inhibitors & Agonists1
- Natural Products1
4,5-Dimethoxycanthin-6-one
Methylnigakinone
TN301318110-87-7
4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity against Staphylococcus aureus and its drug-resistant strains. It is a potent, non-competitive inhibitor of CYP1A2-mediated phenacetin O-deethylation (IC50: 1.7 μM, Ki: 2.6 μM) and a potent inhibitor of cyclic adenosine monophosphate (cAMP) phosphodiesterase. Additionally, it exhibits cytotoxicity to tumor cell lines U937 and HepG2.
- $73
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