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PROTAC SMARCA2/4-degrader-32
T2004812568273-79-8
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting both SMARCA2 and SMARCA4 proteins. In A549 cells, it shows DC50s values for the degradation of SMARCA2/4 proteins <100 nM and achieves a maximum degradation rate (Dmax%) of >90 after 24 hours of treatment.
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