1207753-03-4

Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthase inhibitor with antifungal activity, disrupting fungal cell wall integrity, used in fungal infection research.

SCY-078 phosphate is a novel glucan synthesis inhibitor.

Ibrexafungerp citrate is a triterpenoid antifungal agent that inhibits the synthesis of 1,3-β-D-glucan in fungal cell walls, and although its functional outcome is similar to echinocandins, it binds to a distinct site on the glucan synthase enzyme, resulting in limited cross-resistance. Ibrexafungerp citrate exhibit concentration-dependent fungicidal activity against Candida species and retaining strong in vitro efficacy against the majority of fluconazole-resistant strains, supporting its use in antifungal resistance and drug development research.