Alkaloids

Alkaloids are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. Alkaloids have a wide range of pharmacological activities including antimalarial (e.g. quinine), antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine), cholinomimetic (e.g. galantamine), vasodilatory (e.g. vincamine), antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. piperine). Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic (e.g. psilocin) and stimulant activities (e.g. cocaine, caffeine, nicotine, theobromine), and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too (e.g. atropine, tubocurarine).

Cat No.	product name
T0486L	Irinotecan Hydrochloride	Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active m...
T2714	Rotundine	Rotundine is extracted from Corydalis yanhusuo W. T. Wang.
T3026	(-)-Huperzine A	Huperzine A, an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibi...
T2S1720	Huperzine B	1. Huperzine-B is a efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates fo...
T8016	N-Benzylmethylamine	N-Benzylmethylamine is an Alkaloids
TN1176	10-Nitro-camptothecin	10-Nitro-camptothecin is a natural product
T2718	Palmatine chloride	Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T0022	Taurine	Taurine, an organic acid, is distributed in various animal tissues.
T3243	Betaine	Betaine is a methyl derivative of glycine first isolated from sugar beets. It has been shown to have potential benefits for fighting heart disease, improving bo...
T5061	Lumichrome	Lumichrome is a natural metabolite of riboflavin. Lumichrome produced by Rhizobium and other bacterial species induces major developmental changes in plants at ...
T4S1869	12-Epinapelline	12-Epinapelline is a diterpene alkaloid which displays anaesthetic activity as toxic neurological agents. Similar to aconitine, its suggested that modulation of...
T3232	Higenamine Hydrochloride
TN2325	(Z)-Akuammidine	(Z)-Akuammidine is a natural product
TN1192	16-Epivoacarpine	16-Epivoacarpine is a natural product from Gelsemium elegans.
TN1746	Humantenidine	Standard reference
T2726	Sinomenine	Sinomenine is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.
TQ0160	Hydrastine	Hydrastine is a natural alkaloid that is present in Hydrastis Canadensis.
T0012	Cinchonine	Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local nar...
T1174	Topotecan hydrochloride	Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer.
T4S0051	Coptisine sulfate	1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
T5595	Tropine	Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family. It serves as an intermediate in the synthesis of a v...
TN1752	Hydroxyevodiamine	Hydroxyevodiamine is a natural product
T5784	Topotecan	Topotecan is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
TN1026	Vomicine	Vomicine is a natural product from Strychnos nux-vomica, the S. nux-vomica extracts show antihyperglycemic activity in experimental animals.
T4183	lavendustin A	lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
T4036	Solasodine	Solasodine(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity agai...
TJS1226	Aristolactam I	A natural compound from the herbs of Aristolochia debilis Sieb. et Zucc
TN1164	1-(3,4-Dimethoxycinnamoyl)piperidine	1-(3,4-Dimethoxycinnamoyl)piperidine is a natural product
T3S0128	Hydroprotopine	Hydroprotopine, treatment for coronary heart disease and angina, and the treatment effect is remarkable.
TN1627	Euojaponine D	Euojaponine D is a natural product
TN2352	Pingpeimine C	Pingpeimine C Derived from Fritillaria sibiricum.
TQ0192	Senecionine	Senecionine is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris.
T2S2362	Dehydrocorydaline nitrate	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effec...
T5S0761	Nitidine chloride	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC...
T4S0794	(R)-(+)-Corypalmine	1. (R)-(+)-Corypalmine shows strong papaverine-like activity.
T0690	Quinine	Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cra...
T7786	Tryptanthrin	Tryptanthrin is a natural DNA gyrase inhibitor。
TN2203	Senecionine N-oxide	Senecionine N-oxide and senecionine have hepatotoxic activity, no antifertility effects in MeOH extract-treated hamsters.
T3S1227	Aristololactam I	1. Aristololactam I has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I ma...
TN1925	Methyl anthranilate	Methyl anthranilate is a natural product
T4S0536	Bullatine A	1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the trea...
T1156	Palonosetron hydrochloride	Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
T5S0661	Koumine	1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a signi...
T5765	ranaconitine	Ranaconitine is an important diterpenoid alkaloid from Aconitum sinomontanum Nakai,ranaconitine has cardiotoxicity.
T0486	Irinotecan hydrochloride trihydrate	Irinotecan HCl-trihydrate keeps DNA from unwinding by inhibiting topoisomerase 1.
T8182	Guan-fu base A	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
T7056	Dronedarone	Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T4953	Neotuberostemonine	Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM...
TN2206	Shancigusin I	Shancigusin I is a natural from Cremastra appendiculata.
T1334	Hydroquinidine	Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
T1668	Vinblastine sulfate	Vinblastine sulfate can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
T2746	Sophocarpine	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
TCS2185	Yohimbine	Yohimbine is a nonselective alpha 2-adrenergic receptor (AR) antagonist(IC50 : 0.6 μM)
T2O2683	proline	1. L-Proline is an osmoprotectant. 2. Proline and its derivatives are often used as asymmetric catalysts in organic reactions, as the CBS reduction and proline...
T0186	Docetaxel trihydrate	Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the th...
T1231	Pilocarpine nitrate	Pilocarpine nitrate is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
T7097	Cytochalasin B	Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).
T2183	Scopolamine butylbromide	Scopolamine butylbromide is a competitive antagonist of mAChR (IC50: 55.3 ± 4.3 nM).
TN2240	Strictosidinic acid	Strictosidinic acid has an antiradical action against DPPH, it has a promising effect in the central nervous system.
TN2370	6- Methoxydihydrosanguinarine	6-Methoxy Dihydrosanguinarine is an lkaloid isolated from the fruits of M.cordata. 6-Methoxy Dihydrosanguinarine.
TN1099	Dihydroevocarpine	Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is ...
TN1121	Evocarpine	Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
T8161	Vicine	Vicine, an alkaloid found in fava beans, is toxic in individuals and may cause haemolytic anaemia.
T4S0795	Berberrubine	1. Berberrubine has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in th...
T3S2340	Usaramine	Usaramine demonstrates phytotoxicity against Lactuca sativa var. Carrascoy (lettuce) assessed as inhibition of seed germination at 50 ug/cm2 after 24 hr.
T3S1457	Palmatrubine	Palmatrubine shows high antitumor activity.
T1286	Vincamine	Vincamine is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cere...
TN2200	Segetalin A	Segetalin A has estrogen-like activity.
T7939	Fingolimod	Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
TN1749	Huperzine C	Huperzine has the value as pretreatment of organophosphate poisoning, it can be used as a protective agent against organophosphate intoxication.
TN1340	7beta-Hydroxyrutaecarpine	7beta-Hydroxyrutaecarpine is a natural product from Euodia ruticarpa.
T7026	KukoaMine B	Kukoamine B is a component of Lycii Cortex, with anti-oxidant, anti-acute inflammatory and anti-diabetic properties.
TN1444	bis[6-(5,6-dihydrochelerythrinyl)]amine	BIS-[6-(5,6-dihydro-chelerythrinyl)] ether shows strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA).
T2754	Oxymatrine	Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis...
TN1129	Protostemotinine	Protostemotinine is a natural product from Stemona japonica.
T8175	Laudanosine	Laudanosine is a recognized metabolite of atracurium and cisatracurium.
T4116	Ademetionine	S-ADENOSYL-L-METHIONINE (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinom...
TN1452	Broussonetine A	Broussonetines A-H are glycosidase inhibitors.
TQ0258	Corynoxine B	Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
TN1070	Aristolochic acid D	Chinese-herb nephropathy (CHN) is a rapidly progressive renal fibrosis associated with the intake of a Chinese herb (Aristolochia fangchi) containing nephrotoxi...
T0970	Anisodamine	Anisodamine is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
T6S0105	Peiminine	1. Peiminine is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury.
TQ0264	Nigakinone	Nigakinone, isolated from Kumu, is one alkaloid with the pharmacological activity.
T6S0033	Crotonoside	1. Crotonoside has much more active than adenosine in reducing the blood pressure in rabbits and cats,in decreasing the tone of isolated intestinal strips of th...
TN1353	(9Z,12Z)-N-Benzyloctadeca-9,12-dienamide	(9Z,12Z)-N-Benzyloctadeca-9,12-dienamide is a natural product
TJS0123	Arecoline	Arecoline is found in nuts. Arecoline is isolated from betel nuts Arecoline is an alkaloid natural product found in the areca nut, the fruit of the areca palm (...
T8185	Viroallosecurinine	(+)-Viroallosecurinine is a natural alkaloid with antibacterial activity. It exhibits a MIC of 0.48 μg/mL for Ps. Aeruginosa and Staph. aureus.
TN1393	(-)-Anonaine	(-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DN...
T2S1200	Sinapine	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant...
T6S2356	(+)-Corynoline	1. Corynoline is an acetylcholinesterase inhibitor.
T5S2357	Acetylcorynoline	1. Acetylcorynoline has antifungal、anti-inflammatory activity. 2. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of ...
TJS0312	7-hydroxy-4-methyl-8-nitrocoumarin
T3901	Solasonine	Solasonine exerts leishmanicidal activity against promastigote forms of L. amazonensis.
T0086	Galanthamine HBr	Galanthamine hydrobromide, a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
T2764	10-Hydroxycamptothecin	10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
TN1346	8-Oxypalmatine	8-Oxypalmatine is a natural product
TN2023	Oxyepiberberine	Oxyepiberberine is a natural product
TN1142	8-Oxycoptisine	8-Oxycoptisine is a natural product with Anti-inflammatory, analgesic, cooling, antihypertensive, anti-cancer
T5S0106	Peimisine	1. Peimisine can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax ...
TN1559	Dehydrodicentrine	Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.