p53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, and thus functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.

Cat. No.	Product name	CAS No.	Purity
T5S0331	Isoliquiritin	5041-81-6	99.88%
T5S0331	1. Isoliquiritin has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dep...
T6909	NSC348884	81624-55-7	99.91%
T6909	NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer...
T3184	Kevetrin hydrochloride	66592-89-0	99.93%
T3184	Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
T12472	Pifithrin-α, p-Nitro, Cyclic	60477-38-5	99.97%
T12472	Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.
TQ0133	Amifostine thiol dihydrochloride	14653-77-1	98%
TQ0133	WR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protect normal tissues from the toxic effects of certain cancer drugs...
T22980	MIRA-1	72835-26-8	98%
T22980	Restorer of wild-type p53 conformation/cellular function
T6610	NSC-207895	58131-57-0	98%
T6610	NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
T16522	Phenoxodiol	81267-65-4	98%
T16522	Phenoxodiol is a synthetic analog of Genestein and activates the mitochondrial caspase system. Phenoxodiol causes cell cycle arrest in the G1/S phase of the cell...
T2707	Pifithrin-α hydrobromide	63208-82-2	97.71%
T2707	Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.