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p53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, and thus functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.
Cat. No. Product name CAS No. Purity Chemical Structure
T5S0331 Isoliquiritin 5041-81-6 99.88%
1. Isoliquiritin has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dep...
T6909 NSC348884 81624-55-7 99.91%
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer...
T3184 Kevetrin hydrochloride 66592-89-0 99.93%
Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
T12472 Pifithrin-α, p-Nitro, Cyclic 60477-38-5 99.97%
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.
TQ0133 Amifostine thiol dihydrochloride 14653-77-1 98%
WR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protect normal tissues from the toxic effects of certain cancer drugs...
T22980 MIRA-1 72835-26-8 98%
Restorer of wild-type p53 conformation/cellular function
T6610 NSC-207895 58131-57-0 98%
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
T16522 Phenoxodiol 81267-65-4 98%
Phenoxodiol is a synthetic analog of Genestein and activates the mitochondrial caspase system. Phenoxodiol causes cell cycle arrest in the G1/S phase of the cell...
T2707 Pifithrin-α hydrobromide 63208-82-2 97.71%
Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
Isoliquiritin
T5S0331
1. Isoliquiritin has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dep...
NSC348884
T6909
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer...
Kevetrin hydrochloride
T3184
Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
Pifithrin-α, p-Nitro, Cyclic
T12472
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.
Amifostine thiol dihydrochloride
TQ0133
WR-1065 dihydrochloride can activate p53 through a JNK-dependent signaling pathway. It also protect normal tissues from the toxic effects of certain cancer drugs...
MIRA-1
T22980
Restorer of wild-type p53 conformation/cellular function
NSC-207895
T6610
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
Phenoxodiol
T16522
Phenoxodiol is a synthetic analog of Genestein and activates the mitochondrial caspase system. Phenoxodiol causes cell cycle arrest in the G1/S phase of the cell...
Pifithrin-α hydrobromide
T2707
Pifithrin-α is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
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