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Search Results for " raw264.7 "

Targets

23

Compounds

32

Natural Products

Cat No. Product Name Synonyms Targets
T27730 KGP94 KGP-94,KGP 94 Cysteine Protease
KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).
T41302 Itaconate-alkyne ITalk Others
Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its dire...
T1031 Cloxacillin sodium monohydrate Cloxacillin Sodium,Bactopen Antibacterial , Antibiotic
Cloxacillin sodium monohydrate (Cloxacillin Sodium) is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity.
TP1938L RS09 2TFA (1449566-36-2 free base) RS09 2TFA 1449566-36-2(free base) TLR
RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 sp...
T82229 HD-2a
HA-2a inhibits the JAK2/STAT3 pathway by downregulating circDcbld2 expression in RAW264.7 cells [1].
T25356 E17110 E-17110,E 17110
E17110 is an LXRβ agonist. E17110 exhibited a significant activation effect on LXRβ (EC50: 0.72 μmol/L). E17110 also increased the expression of ABCA1 and ABCG1 in RAW264.7 macrophages. E17110 significantly decreased cel...
T83049 Anti-inflammatory agent 63
Anti-inflammatory agent 63 exhibits potent inhibitory activity (EC50 = 5.33±0.57 μM) against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells [1].
T61157 ABAI-30
ABAI-30 is a highly potent and orally bioavailable anti-inflammatory compound that efficiently suppresses nitric oxide (NO) production in lipopolysaccharide (LPS) activated RAW264.7 cells [1].
T79999 NF-κB-IN-13 NF-κB
NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1].
T79130 COX-2-IN-32 NF-κB
COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression. Demonstrating anti-inflammatory properties, it impedes NO production in LPS-induced RAW264.7 macrophages with an IC...
T73061 Amakusamine
Amakusamine effectively suppresses the formation of multinuclear osteocasts triggered by the receptor activator of nuclear factor-κB ligand (RANKL) with an inhibitory concentration (IC50) of 10.5 μM in RAW264.7 cells.
TP1938 RS 09 TLR
TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when adm...
T75952 RS 09 TFA
RS 09 TFA, a TLR4 agonist, promotes NF-κB nuclear translocation and induces the secretion of inflammatory cytokines in RAW264.7 macrophages in vitro. Additionally, as an adjuvant in vivo, RS 09 TFA enhances serum concent...
T78750 NF-κB-IN-10 NF-κB
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviating oxidative stress and inflammation. It suppresses LPS-induce...
T60433 NF-κB-IN-6
NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling pathway. NF-κB-IN-6 inhibits the production of NO in LPS-induced R...
T78056 HMGB1-IN-1
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/NLRP3 signaling pathway. This compound demonstrates promising...
T64210 ATX inhibitor 13
ATX inhibitor 13 (compound 10c) is an orally active ATX inhibitor (IC50: 3.4 nM). ATX inhibitor 13 is capable of blocking the cell cycle of RAW264.7 cells in the G2 phase, inhibiting cell proliferation and migration and ...
T79620 Anti-inflammatory agent 55
Compound 9j (anti-inflammatory agent 55), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of iNOS, TNF-α, IL-6, and IL-1β. It notably suppresses LPS-...
T79619 Anti-inflammatory agent 54
Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of pro-inflammatory cytokines such as iNOS, TNF-α, IL-6, an...
T36486 Benpyrine
Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten...
T62317 α7 nAchR-JAK2-STAT3 agonist 1
α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β...
T82189 HMGB1-IN-2
HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces...
T37614 LDN-0088050
LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1]. Ki: 0.29 μ...
Cat No. Product Name Synonyms Targets
TN1109 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid NOS , NO Synthase , Prostaglandin Receptor
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
TN6750 2-tert-Butyl-1,4-benzoquinone Nrf2
2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.
T5727 CAFESTOL ERK , NF-κB , COX , PGE Synthase
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production...
TN2167 Rutaevin Reactive Oxygen Species , NO Synthase
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.
T3927 Phellopterin GABA Receptor
Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCA...
T6S1543 Dehydrodiisoeugenol Others , NF-κB , COX , Antibacterial
1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ...
T5S0581 Sec-O-Glucosylhamaudol Hamaudol 3-glucoside Others , Opioid Receptor
Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal Sec-O-Glucosylhamaudo...
T3929 Kaurenoic acid Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid Others
Kaurenoic acid (kaurenoate) has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part,...
T6S0139 Neobavaisoflavone Apoptosis , DNA/RNA Synthesis
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...
TN1712 Gossypin NF-κB , S6 Kinase
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role i...
T2S1907 Coniferaldehyde Ferulaldehyde,Ferulyl aldehyde,4-HYDROXY-3-METHOXYCINNAMALDEHYDE,Coniferyl aldehyde Apoptosis , Antioxidant
Coniferaldehyde (Ferulaldehyde) is a member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3. It has a role as an antifungal agent and ...
T4S1615 Sanggenon C Sanggenone C NF-κB
1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO pro...
TN4633 Neocryptotanshinone II NOS , NF-κB
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
T72578 Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.
T38820 Methylsyringin
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.
TN4244 Icariside B1 Akt
Icariside B1 shows inhibitory effects on LPS-induced NO production in RAW264.7 cells.
TMA1241 Apterin Others
Apterin has anti-inflammatory activity in vitro, it shows significantly inhibitory activity on nitric oxide production in RAW264.7 cells.
TN4047 Excisanin B Others
Excisanin B shows inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.
T75615 Inflexuside B
Inflexuside B, an abietane diterpenoid derived from the aerial parts of Isodon inflexus, effectively inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages [1].
T79992 Sarglaroids F Caspase
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+ efflux and diminishing Caspase-1(P20) concentrations. Additional...
T75691 Amaroswerin
Amaroswerin, a bioactive secoiridoid glucoside derived from Swertia mussotii, exhibits anti-inflammatory, antidiabetic, antiviral, anticholinergic, and immunomodulatory properties. It notably inhibits nitric oxide (NO) r...
TN3241 7-O-Acetylbonducellpin C Others
7-O-Acetylbonducellpin C may exhibit significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).
TQ0073 Andropanolide HIV Protease , NO Synthase , Parasite
Andropanolide is a dipterocarbon from Andrographis paniculata with anti-HIV, antimalarial and anticancer activities and inhibits Lipopolysaccharides (LPS)-stimulated overproduction of nitric oxide (NO) in RAW264.7 macrop...
T75616 Inflexuside A
Inflexuside A, an abietane diterpenoid isolated from the aerial parts of Isodon inflexus, and Inflexuside B significantly inhibit lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages [1]...
T79970 Taxamairin B
Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and reduces the production of NO and ROS in LPS-induced RAW264.7 cells. Furthermore, ...
T79930 Sanggenon A Sanggenone A NF-κB
Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and it significantly suppresses Lipopolysaccharide (LPS)-induced nitric...
TN4146 Glutinol acetate TNF
Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits mo...
TN1638 Evodol Others
Evodol may as an anti-inflammatory agent or lead compound, it shows inhibitory activity on nitric oxide (NO) production in lipopolysaccharide -activated RAW264.7 macrophages. Evodol and limonin possess larvicidal activit...
TN4635 Neoechinulin A NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ...
TN4580 Morachalcone A Tyrosinase
Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-...
TN4064 Flavoglaucin Phosphatase , IL Receptor , TNF , NOS , NF-κB , COX , Nrf2 , Prostaglandin Receptor , Autophagy
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor pr...
TN4411 Lappaol F CDK , P-gp , JNK
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be c...

Natural Products

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
TN1109
Synonym: 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
Target: NOS, NO Synthase, Prostaglandin Receptor
2-tert-Butyl-1,4-benzoquinone
TN6750
Synonym:
Target: Nrf2
CAFESTOL
T5727
Synonym:
Target: ERK, NF-κB, COX, PGE Synthase
Rutaevin
TN2167
Synonym:
Target: Reactive Oxygen Species, NO Synthase
Phellopterin
T3927
Synonym:
Target: GABA Receptor
Dehydrodiisoeugenol
T6S1543
Synonym:
Target: Others, NF-κB, COX, Antibacterial
Sec-O-Glucosylhamaudol
T5S0581
Synonym: Hamaudol 3-glucoside
Target: Others, Opioid Receptor
Kaurenoic acid
T3929
Synonym: Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid
Target: Others
Neobavaisoflavone
T6S0139
Synonym:
Target: Apoptosis, DNA/RNA Synthesis
Gossypin
TN1712
Synonym:
Target: NF-κB, S6 Kinase
Coniferaldehyde
T2S1907
Synonym: Ferulaldehyde,Ferulyl aldehyde,4-HYDROXY-3-METHOXYCINNAMALDEHYDE,Coniferyl aldehyde
Target: Apoptosis, Antioxidant
Sanggenon C
T4S1615
Synonym: Sanggenone C
Target: NF-κB
Neocryptotanshinone II
TN4633
Synonym:
Target: NOS, NF-κB
Siegesbeckialide I
T72578
Synonym:
Target:
Methylsyringin
T38820
Synonym:
Target:
Icariside B1
TN4244
Synonym:
Target: Akt
Apterin
TMA1241
Synonym:
Target: Others
Excisanin B
TN4047
Synonym:
Target: Others
Inflexuside B
T75615
Synonym:
Target:
Sarglaroids F
T79992
Synonym:
Target: Caspase
Amaroswerin
T75691
Synonym:
Target:
7-O-Acetylbonducellpin C
TN3241
Synonym:
Target: Others
Andropanolide
TQ0073
Synonym:
Target: HIV Protease, NO Synthase, Parasite
Inflexuside A
T75616
Synonym:
Target:
Taxamairin B
T79970
Synonym:
Target:
Sanggenon A
T79930
Synonym: Sanggenone A
Target: NF-κB
Glutinol acetate
TN4146
Synonym:
Target: TNF
Evodol
TN1638
Synonym:
Target: Others
Neoechinulin A
TN4635
Synonym:
Target: NADPH-oxidase, Beta Amyloid, ASK, IκB/IKK, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor
Morachalcone A
TN4580
Synonym:
Target: Tyrosinase
Flavoglaucin
TN4064
Synonym:
Target: Phosphatase, IL Receptor, TNF, NOS, NF-κB, COX, Nrf2, Prostaglandin Receptor, Autophagy
Lappaol F
TN4411
Synonym:
Target: CDK, P-gp, JNK
TargetMol