Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Cat. No.	Product name	CAS No.	Purity
TN1989	Niga-ichigoside F1	95262-48-9	98%
TN1989	Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.
T15474	Hesperin	4430-35-7	98%
T15474	Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
TN2336	Rehmapicrogenin	135447-39-1	98%
TN2336	Rehmapicrogenin regulates the Nrf2/ARE signaling pathway. Nrf2/ARE signaling pathway is the most important pathway of oxidative stress.
TN4064	Flavoglaucin	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
T11251	Ezetimibe ketone	191330-56-0	98%
T11251	Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.Ezetimibe ketone ...
TN1151	Procyanidol B4	29106-51-2	98%
TN1151	Procyanidin B4 reveals significant antioxidant activity
TQ0199	Ginsenoside Rh3	105558-26-7	98%
TQ0199	Ginsenoside Rh3 is a natural product extracted from Panax ginseng C. A. Mey. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.
T60487	DDO-7263	2254004-96-9	98%
T60487	DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of...
TMA0237	Carlinoside	59952-97-5	98%
TMA0237	Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclea...
TN3726	Cudraflavone B	19275-49-1	98%
TN3726	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN4420	Latifolin	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TN6711	Toralactone	41743-74-2	98%
TN6711	Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism
TN1548	6"-O-Malonyldaidzin	124590-31-4	98%
TN1548	Daidzin 6''-O-malonate may have anticancer activity.
T16352	NSC23925	858474-14-3	98%
T16352	NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
T11758L	KI696	1799974-70-1	98%
T11758L	KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.
T2A2486	3',4',5',5,7-Pentamethoxyflavone	53350-26-8	98%
T2A2486	3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adju...
TN1670	Ganodermanondiol	107900-76-5	98%
TN1670	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TN1058	Pelargonidin chloride	134-04-3	98%
TN1058	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
TN5278	Zederone	7727-79-9	98%
TN5278	Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TN3806	Dehydroglyasperin C	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...