MEK

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.

Cat. No.	Product name	CAS No.	Purity
T6057	URMC-099	1229582-33-5	99.32%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T36631	BAY-6035	2247890-13-5	99.39%
T36631	BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.
T5S2361	Epiberberine	6873-09-2	99.58%
T5S2361	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
T3001	Honokiol	35354-74-6	99.65%
T3001	Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
T2623	PD98059	167869-21-8	99.66%
T2623	PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
T6152	PD318088	391210-00-7	99.69%
T6152	PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-bi...
T2125	Trametinib	871700-17-3	99.71%
T2125	Trametinib is an ATP-noncompetitive inhibitor of MEK 1/2 (IC50s: 0.7/0.9 nM). It shows low inhibition for more than 180 kinases, including B-Raf, c-Raf, and MEK5...
T5857	Trametinib (DMSO solvate)	1187431-43-1	99.71%
T5857	Trametinib DMSO solvate is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)
T0468	Lidocaine	137-58-6	99.74%
T0468	Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellul...
T2708	SL327	305350-87-2	99.74%
T2708	SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
T6223	U0126-EtOH	1173097-76-1	99.82%
T6223	U0126-EtOH is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).
T1144	Lidocaine hydrochloride	73-78-9	99.83%
T1144	Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
T2327	Pelitinib	257933-82-7	99.86%
T2327	Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
T2416	BIX02189	1094614-85-3	99.86%
T2416	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
T6189	Mirdametinib	391210-10-9	99.91%
T6189	PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).
T2378	RGB-286638 free base	784210-88-4	99.91%
T2378	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3...
T2P2806	Hederacolchiside A1	106577-39-3	99.92%
T2P2806	Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering mem...
T3623	Cobimetinib	934660-93-2	99.98%
T3623	Cobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalyti...
T27242	EF24	342808-40-6	98%
T27242	EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity i...
T14055	5Z-7-Oxozeaenol	253863-19-3	98%
T14055	5Z-7-Oxozeaenol, a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of...