T6057 |
URMC-099
|
1229582-33-5
|
99.32%
|
|
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
|
T36631 |
BAY-6035
|
2247890-13-5
|
99.39%
|
|
BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.
|
T5S2361 |
Epiberberine
|
6873-09-2
|
99.58%
|
|
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
|
T3001 |
Honokiol
|
35354-74-6
|
99.65%
|
|
Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
|
T2623 |
PD98059
|
167869-21-8
|
99.66%
|
|
PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
|
T6152 |
PD318088
|
391210-00-7
|
99.69%
|
|
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-bi...
|
T2125 |
Trametinib
|
871700-17-3
|
99.71%
|
|
Trametinib is an ATP-noncompetitive inhibitor of MEK 1/2 (IC50s: 0.7/0.9 nM). It shows low inhibition for more than 180 kinases, including B-Raf, c-Raf, and MEK5...
|
T5857 |
Trametinib (DMSO solvate)
|
1187431-43-1
|
99.71%
|
|
Trametinib DMSO solvate is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)
|
T0468 |
Lidocaine
|
137-58-6
|
99.74%
|
|
Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellul...
|
T2708 |
SL327
|
305350-87-2
|
99.74%
|
|
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
|
T6223 |
U0126-EtOH
|
1173097-76-1
|
99.82%
|
|
U0126-EtOH is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).
|
T1144 |
Lidocaine hydrochloride
|
73-78-9
|
99.83%
|
|
Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
|
T2327 |
Pelitinib
|
257933-82-7
|
99.86%
|
|
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
|
T2416 |
BIX02189
|
1094614-85-3
|
99.86%
|
|
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
|
T6189 |
Mirdametinib
|
391210-10-9
|
99.91%
|
|
PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).
|
T2378 |
RGB-286638 free base
|
784210-88-4
|
99.91%
|
|
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3...
|
T2P2806 |
Hederacolchiside A1
|
106577-39-3
|
99.92%
|
|
Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering mem...
|
T3623 |
Cobimetinib
|
934660-93-2
|
99.98%
|
|
Cobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalyti...
|
T27242 |
EF24
|
342808-40-6
|
98%
|
|
EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity i...
|
T14055 |
5Z-7-Oxozeaenol
|
253863-19-3
|
98%
|
|
5Z-7-Oxozeaenol, a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of...
|