Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.

Cat. No.	Product name	CAS No.	Purity
T0746	Orotic acid	65-86-1	99.93%
T0746	Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
T1165	Ethionamide	536-33-4	99.92%
T1165	Ethionamide (2-ethylthioisonicotinamide) is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of a...
T1159	Leflunomide	75706-12-6	99.9%
T1159	Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
T7964	Isomalt	64519-82-0	99.88%
T7964	Isomalt (Palatinitol) is a mixture of 1,6-mannitol glucopyranoside and 1,6-sorbitol glucopyranoside
T11023	DHODH-IN-14	1364791-93-4	99.87%
T11023	DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHOD...
T5325	Nifurtimox	23256-30-6	99.87%
T5325	Nifurtimox (BAY-A-2502) is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T. cruzi- epimastigotes, respec...
T3604	Sodium dichloroacetate	2156-56-1	99.87%
T3604	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has ...
T2346L	Enasidenib mesylate	1650550-25-6	99.86%
T2346L	Enasidenib mesylate (AG-221 mesylate) is a potent and selective IDH2 mutase inhibitor that promotes differentiation of leukemia myeloid cells for the treatment o...
T79745	IDH2R140Q-IN-2	2749568-16-7	99.85%
T79745	IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG pro...
T13774	ML390	2029049-79-2	99.85%
T13774	ML390 exerts its potent differentiation effect on multiple leukemia models.
T11020	DHODH-IN-11	1263303-95-2	99.84%
T11020	DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
T11829	LDH-IN-1	1964515-43-2	99.84%
T11829	LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
T0684	Ribavirin	36791-04-5	99.83%
T0684	Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T11031	HDHODH-IN-7	1644156-41-1	99.82%
T11031	hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral eff...
T60240	ALDH1A3-IN-2	886502-08-5	99.82%
T60240	ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.
T38163	ML-148	451496-96-1	99.81%
T38163	ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydr...
T6518	Gossypol	303-45-7	99.8%
T6518	Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
T6903	NCT-501	1802088-50-1	99.79%
T6903	NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
TN2373	(E/Z)-Ginkgolic acid C17:2	102811-39-2	99.78%
TN2373	(E/Z)-Ginkgolic acid C17:2 (Ginkgolic Acid C17:2) is a natural product that can be extracted from Ginkgo biloba and targets human dihydroorotic acid dehydrogenas...
T15435	GSK2837808A	1445879-21-9	99.78%
T15435	GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).