T15551 |
IDH889
|
1429179-07-6
|
98%
|
|
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μ...
|
T9974 |
WAY-324168
|
663214-48-0
|
98%
|
|
WAY-324168 is a compound with antiproliferative activity.
|
T37190 |
L-Allylglycine
|
16338-48-0
|
98%
|
|
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
|
T9494 |
3-(IMIDAZOL-4-YL)PROPIONIC ACID
|
1074-59-5
|
98%
|
|
3-(IMIDAZOL-4-YL)PROPIONIC ACID is a product of histidine metabolism and may involve oxidation or transamination. 3-(IMIDAZOL-4-YL)PROPIONIC ACID is potent inhib...
|
T0010 |
6-Mercaptopurine
|
50-44-2
|
98%
|
|
Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabo...
|
T60149 |
11β-HSD1-IN-11
|
859721-81-6
|
98%
|
|
11β-HSD1-IN-11 is a competitive 11β-HSD1 inhibitor with IC50s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively.
|
T40686 |
Tiazofurin
|
60084-10-8
|
98%
|
|
Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotid...
|
T16510 |
PF-915275
|
857290-04-1
|
98%
|
|
The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF...
|
T14388 |
AZD 4017
|
1024033-43-9
|
98%
|
|
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
|
T11027 |
DHODH-IN-4
|
1148125-93-2
|
98%
|
|
DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, resp...
|
T9859 |
SW209049
|
1673558-59-2
|
98%
|
|
SW209049 is a stearoyl-CoA 9-desaturase inhibitor. SW209049 exhivits potent activity against H2122 cell with IC50 of 0.13uM.
|
T12196 |
NCT-505
|
2231079-74-4
|
98%
|
|
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1)(IC50 of 7 nM).
|
TJS1382 |
Taraxerone
|
514-07-8
|
|
|
Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease i...
|
T0054 |
Disulfiram
|
97-77-8
|
|
|
Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the interme...
|
T10140 |
4-Diethylaminobenzaldehyde
|
120-21-8
|
|
|
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71μ...
|
T19831 |
Sodium Oxamate
|
565-73-1
|
|
|
Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis th...
|
T7741 |
DS-1001b
|
1898207-64-1
|
100%
|
|
DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1)
|
T14884 |
CBR-5884
|
681159-27-3
|
100%
|
|
CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer...
|
T8480 |
Tenovin-6 Hydrochloride
|
1011301-29-3
|
100%
|
|
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
|
T11021 |
DHODH-IN-12
|
1263303-93-0
|
100%
|
|
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
|