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DUB

Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions.DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases.
Cat. No. Product name CAS No. Purity Chemical Structure
T60146 USP8-IN-1 2477650-96-5 98.01%
USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].
T11485 GSK2643943A 2449301-27-1 98.06%
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
T11209 EOAI3402143 1699750-95-2 98.09%
EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits  Usp5/Usp24 andUsp9x.
T2424 P 22077 1247819-59-5 98.42%
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
T9217 USP7-IN-8 2009273-60-1 98.48%
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. US...
T4338 USP7/USP47 inhibitor 1247825-37-1 98.5%
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
T11111 DUB-IN-2 924296-19-5 98.53%
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
T13268 USP7-IN-1 1381291-36-6 98.70%
USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 77 μM) and used for cancer.
T9122 XL177A 2417089-74-6 98.75%
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
T15464 HBX 19818 1426944-49-1 98.76%
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
T6107 IU1 314245-33-5 99.11%
IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
T8464 RA-9 919091-63-7 99.31%
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
T7678 SJB2-043 63388-44-3 99.35%
SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
T11110 DUB-IN-1 924296-18-4 99.45%
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
T6697 TCID 30675-13-9 99.47%
TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
T60130 USP5-IN-1 99.53%
USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor, which binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins contai...
T15604 IU1-47 670270-31-2 99.55%
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
T5461 GNE-6640 2009273-67-8 99.59%
GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, US...
T3555 ML364 1991986-30-1 99.77%
ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.
T11464 GRL0617 1093070-16-6 99.77%
GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).
USP8-IN-1
T60146
USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].
GSK2643943A
T11485
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
EOAI3402143
T11209
EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits  Usp5/Usp24 andUsp9x.
P 22077
T2424
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
USP7-IN-8
T9217
Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. US...
USP7/USP47 inhibitor
T4338
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
DUB-IN-2
T11111
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
USP7-IN-1
T13268
USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 77 μM) and used for cancer.
XL177A
T9122
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
HBX 19818
T15464
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
IU1
T6107
IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
RA-9
T8464
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
SJB2-043
T7678
SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
DUB-IN-1
T11110
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
TCID
T6697
TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
USP5-IN-1
T60130
USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor, which binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins contai...
IU1-47
T15604
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
GNE-6640
T5461
GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, US...
ML364
T3555
ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.
GRL0617
T11464
GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).
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