xanthomonas citri

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp. It exhibits selective antibacterial activity against Xanthomonas species, inhibiting Xanthomonas citri, Xanthomonas oryzae, and phage with MIC values of 0.4 μg/mL, 12.5 μg/mL, and 12.5 μg/mL respectively.

ROS inducer 1 is a small molecule compound with bactericidal activity that inhibits the production of ROS in Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo) and Pseudomonas syringae pv. actinidiae (Psa). ROS inducer 1 induces ROS production in Xanthomonas cells and can be used to study bacterial infections in crops.

Antibiofilm agent-3 (compound 3b) is a tetraformamide antibacterial compound that effectively inhibits the plant bacterial pathogen Xanthomonas citri ssp. citri (Xcc) with a minimum inhibitory concentration (MIC) of 500 μg/mL. It also suppresses biofilm formation of Xcc, with an IC50 of 15.37 μg/mL.

Quorum sensing-IN-5 is an RpfF-targeted quorum-sensing inhibitor. It suppresses Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) with EC50 values of 9.91 μg/mL and 7.04 μg/mL, respectively. Quorum sensing-IN-5 exhibits antimicrobial activity.

Antibacterialagent 292 is a derivative of 3-pyrazolylindole and functions as an antibacterial agent. It exhibits potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 μg/mL and 3.49 μg/mL, respectively. It inhibits biofilm formation, bacterial motility, and extracellular polysaccharide production, induces morphological changes, promotes reactive oxygen species (ROS) accumulation, and leads to bacterial apoptosis. Additionally, it downregulates gene expression related to the type VI secretion system (T6SS). Antibacterialagent 292 can be applied in the management of bacterial leaf blight in rice and citrus canker.

Antibacterialagent 296 (Compound Q24) is an antimicrobial substance that inhibits biofilm formation and reduces extracellular polysaccharides. It exhibits inhibitory activity against Xanthomonas axonopodis pv. citri (Xac), with an EC50 value of 5.13 μg/mL.

Antibacterialagent 316 (Compound C1-15) is an antibacterial agent. It exhibits antibacterial activity against Xanthomonas oryzae pv oryzae, Xanthomonas axonopodis pv citri, and Pseudomonas solanacearum, with a MIC range of 1.56 to 6.25 μg/mL. Additionally, Antibacterialagent 316 shows antifungal activity against Rhizoctonia solani and Botrytis cinerea.