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vhl ligand 2 dihydrochloride

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
  • PROTAC Products
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    TargetMol | PROTAC
(S,R,S)-AHPC-Me dihydrochloride
VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
T13671L
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.
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(S,R,S)-AHPC-PEG2-NH2 dihydrochloride
VH032 amide-PEG2-amine, VH032-PEG2-NH2 dihydrochloride, VH032-linker 12
T186752341796-76-5
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker[1].
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