vacv

Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, the drug is low in toxicity.

ssVACV-70mer sodium is a 70 bp single-stranded oligonucleotide containing a viral DNA motif derived from vaccinia virus DNA. Unlike its double-stranded counterpart, dsVACV 70mer, ssVACV-70mer sodium does not act as an IFN inducer.

dsVACV-70mer sodium is a 70 base pair double-stranded oligonucleotide that contains a viral DNA motif derived from vaccinia virus DNA. It effectively induces IFN-β through a STING-dependent mechanism.

ITGB3-IN-1 is an orally active integrin β3 subunit (ITGB3) inhibitor with a Kd of 7.26 μM. This compound demonstrates potent anti-orthopoxvirus activity, exhibiting an EC50 of 1.82 μM against vaccinia virus (VACV). ITGB3-IN-1 also inhibits hERG with an IC50 of 1.13 μM and can be utilized in orthopoxvirus research.

Antiviralagent 74 is an antiviral compound that consists of a Cidofovir prodrug linked to a lipid chain. After conversion to Cidofovir, Antiviralagent 74 inhibits the activity of viral DNA polymerase. It demonstrates potent antiviral activity against vaccinia virus (VACV) with an EC50 value of 0.156 μM, comparable to the activity of Brincidofovir. Its efficacy against monkeypox virus (MPXV) is even greater, with an EC50 value of 0.202 μM. Antiviralagent 74 is applicable in the study of viral infections.

Monkeypox virus resolvase-IN-1 (compound 5-1) is a potent inhibitor of the monkeypox virus resolvase (Mpr), with an IC50 of 36 nM. It exhibits antiviral activity against the vaccinia virus (VACV, a model orthopoxvirus), with an EC50 of 3.2 nM. Monkeypox virus resolvase-IN-1 is applicable in antiviral research.

ZW-2038 is a potent and selective antiviral compound effective against Vaccinia virus (VACV), Monkeypox virus (MPXV), and Cowpox virus (CPXV). It inhibits VACV DNA replication and subsequent post-replicative gene expression, although it does not inhibit MPXV protease (Mpr). ZW-2038 demonstrates strong antiviral activity in complex human and animal tissue models and can be used for research on Orthopoxvirus infections.

Antiviral agent 33 (compound 1c), a double-stranded DNA (dsDNA) virus inhibitor, exhibits potent inhibitory activity with IC50 values of 0.0790 µM for VACV and 0.1572 µM for AdV5, and is a candidate for oral administration [1].