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uni pr129

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UniPR129
UniPR-129, UniPR 129
T263101639159-47-9
UniPR129 is a highly selective, cell-permeable, competitive Eph/ephrin antagonist belonging to the class of L-tryptophan derivatives of lithocholic acid. UniPR129 inhibits the interaction between EphA2 and ephrin-A1 with an IC₅₀ of 945 nM and a Ki of 345 nM. UniPR129 inhibits angiogenesis in HUVEC cells with an IC₅₀ of 5.2 μM. UniPR129 exhibits antitumor and neuroprotective effects and can be used in research on cancer and neurological diseases.
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