uk-122

UK-122 is a potent and selective uPA inhibitor (Ki = 20 nM). The IC(50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK122 showed little cytotoxicity against CFPAC-1 cells (IC(50) > 100 micromol/L) but significantly inhibited the migratio

UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion.

UK122 hydrochloride is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA), with an IC50 of 0.2 μM. It shows little to no inhibitory effect on tissue-type PA (tPA), plasmin, thrombin, and trypsin (IC50 > 100 μM for all). As a 4-oxazolidinone analog, UK122 hydrochloride acts as an anti-cancer agent by inhibiting cancer cell migration and invasion.