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By Target- E1/E2/E3 Enzyme
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Results for "
ubiquitylation
" in TargetMol Product Catalog- Inhibitors & Agonists9
- Compound Libraries1
- PROTAC Products1
- Recombinant Protein6
ARV-471
Vepdegestrant
T397102229711-68-4In house
Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
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