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tie2 kinase inhibitor 1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    5
    TargetMol | Inhibitors_Agonists
Tie2 kinase inhibitor 1
T6335948557-43-5
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor), an optimized compound of SB-203580, is selective to Tie2 with IC50 of 0.25 μM, which is 200-fold more effective than p38.
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AMG-Tie2-1
AMG-Tie2
T22259870223-96-4
AMG-Tie2-1 is a potent inhibitor of endothelial endothelial cell kinase 2 (Tie2) and VEGFR2 with anticancer and antitumor activity that affects cardiovascular production, and may be used in the study of cardiovascular disease and cancer.
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6-8 weeks
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tie2 inhibitor 7
T367181020412-97-8
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.
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6-8 weeks
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N-desmethyl Regorafenib N-oxide
T84977835621-12-0
N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.
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8-10 weeks
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CEP-11981 tosylate
ESK981 tosylate, BOL 303213X tosylate
T86039901128-79-8
CEP-11981 (tosylate) [also known as ESK981 (tosylate), BOL 303213X (tosylate)] is an orally active tyrosine kinase inhibitor (TKI) that targets TIE2, VEGFR1-3, and FGFR1, with potential anti-tumor and anti-angiogenic effects [1].
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10-14 weeks
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