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(3)
By Target- TGF-beta/Smad
- Casein Kinase(1)
- MLK(1)
- RIP kinase(1)
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Results for "
tgfβrii
" in TargetMol Product Catalog- Inhibitors & Agonists4
- Inhibitory Antibodies1
- Isotope Products1
Galunisertib
Cited
LY2157299
T2510700874-72-2
Galunisertib (LY2157299) is a TGF-β receptor type I (TGF-βRI) inhibitor (IC50=56 nM) that is selective. Galunisertib has antitumor activity and can be used in combination with PD-1 inhibitors.
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CitedLY-364947
Cited
LY 364947, HTS466284
T2048396129-53-6
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
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CitedBintrafusp alfa
MSB-0011359C, MSB0011359C, M-7824, M7824, GSK-4045154, GSK4045154
T805881918149-01-5
Bintrafusp alfa (M7824) is a bifunctional fusion protein consisting of the extracellular structural domain of TGF-βRII (a TGF-β trap ) fused to a monoclonal antibody against human immunoglobulin G1 fused to programmed death ligand 1 (PD-L1), which is known for its anticancer activity, and can be used to study esophageal cancer. It has anticancer activity and can be used to study esophageal cancer.
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TGFβRI-IN-1
T131371950628-94-0
TGFβRI-IN-1 is an orally active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase, with IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively.
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