tco peg4 nhs ester

TCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules. As a cleavable and synthetic ADC, it is also utilized in the synthesis of antibody-drug conjugates (ADCs).

(E)-TCO-PEG4-NHS ester is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-GK-PEG4-NHS ester serves as an ADC linker, suitable for synthesizing [18F] AlF-NOTA-Tz-TCO-GK-2Rs15d, which demonstrates high affinity and immunoreactivity to HER2 [1]. This compound is a click chemistry reagent containing a TCO group that can engage in an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

(S)-TCO-PEG4-NHS ester, an ADC linker with four PEG units, utilizes its TCO group to facilitate an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

TCO-PEG4-TFP ester is an amine-reactive labeling reagent used for the modification of proteins, antibodies, and other amine-containing biopolymers. TFP is a reactive ester that demonstrates superior stability during hydrolysis in aqueous media, enhancing the efficiency and reproducibility of biopolymer labeling. The TFP ester of carboxylic acid reacts with primary amines at a rate equivalent to NHS esters, forming a covalent amide bond identical to that produced by the reaction of primary amines with NHS or sulfo-NHS esters.