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Results for "
tac 3
" in TargetMol Product Catalog- Inhibitors & Agonists3
- PROTAC Products1
- Recombinant Protein1
Gefitinib-based PROTAC 3
T54372230821-27-7
Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].
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Amsilarotene
TAC-101, TAC101, TAC 101
T21314125973-56-0
Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.
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