t 91825

T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].

Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens.

Ceftaroline hydrochloride (T-91825 hydrochloride) is a cephalosporin compound characterized as the active form of TAK-599. This compound demonstrates efficacy against both Gram-positive and Gram-negative bacteria. It exhibits antibacterial activity specifically against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), penicillin-intermediate Streptococcus pneumoniae (PISP), and penicillin-resistant Streptococcus pneumoniae (PRSP), with MIC90 values measured at 2 μg/mL, 1 μg/mL, 0.13 μg/mL, and 0.25 μg/mL respectively.

Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection.